Sciatica painkillers to take how long according to the patient’s symptoms and pain tolerance level to determine the patient’s pain relief can be discontinued, generally no more than three months, for more than three months of medication for pain is still not relieved, it is recommended to consider surgical treatment. Sciatica patients with acute pain episodes, under the guidance of a doctor to take non-steroidal anti-inflammatory drugs for analgesia, commonly used ibuprofen, etoricoxib, celecoxib, etc.; severe pain can be short-term use of glucocorticosteroids to alleviate the symptoms, such as tricholamide. Sciatica is mostly caused by lumbar intervertebral disc herniation, etc. For those who have taken medication for 3 months without significant symptomatic relief, surgical treatment can be considered, such as intervertebral disc nucleus pulposus removal, nerve root release surgery, etc. The duration of medication should be determined by the patient’s symptoms and the duration of treatment. The duration of drug treatment depends on the patient’s symptoms and the degree of pain relief, and it is generally not recommended to take drugs for more than 3 months. The above medications should be used in a standardized manner under the guidance of a doctor to avoid adverse effects.