1. Definition: A clinical syndrome caused by reflux of gastric acid and other gastric contents into the esophagus, resulting in cough as a prominent manifestation, which is a special type of GERD and a rare cause of chronic cough. The pathogenesis involves trace aspiration, esophageal-bronchial reflex, dysfunction of esophageal motor function, dysfunction of vegetative nerves and neurogenic inflammation of the airway, etc. Currently, it is thought that neurogenic inflammation of the airway caused by the esophageal-bronchial reflex plays a secondary role. In addition to gastric acid, most patients are also associated with bile reflux. 2, clinical manifestations: typical reflux symptoms manifested as heartburn (searing sensation behind the sternum), acid reflux, belching, etc.. Localized gastroesophageal reflux causes a cough accompanied by typical reflux symptoms, but there are many patients with cough as the only manifestation. The cough mostly occurs in the daytime and in the upright position, with a dry cough or a large amount of white mucous sputum. Eating acidic and light foods can easily induce or alleviate the cough. 3. Diagnostic criteria: (1) Chronic cough, with daytime cough predominant. (2) 24h esophageal pH monitoring Demeester score ≥12.70, and/or SAP ≥75%. (3) The cough is clearly aggravated or faded after anti-reflux treatment. However, it should be noted that patients with a small number of concurrent or non-acid reflux (e.g., bile reflux) may not have abnormal esophageal pH monitoring results, and such patients may be diagnosed with esophageal impedance testing or bile reflux monitoring. For patients with chronic cough in units without esophageal pH monitoring or with limited economic conditions, the following indications can be considered for stopping diagnostic medical treatment. (1) The patient has a distinctive feeding-related cough, such as postprandial cough and feeding cough. (2) Patients with typical reflux symptoms such as heartburn and acid reflux. (3) Sweeping out diseases such as CVA, UACS and EB, or poor results of medical treatment according to these diseases. Take a standard dose of proton pump inhibitor (such as omeprazole 20mg twice a day) and treat for not less than 8 weeks. Anti-reflux treatment after the cough fades or significantly relieved, can be clinically diagnosed GERC. 4, treatment: (1) adjust the lifestyle: overweight patients should lose weight, prevent oversaturated sleep eating, prevent eating acidic, light food, prevent drinking coffee drinks and smoking. (2) acid control drugs: proton pump inhibitors (such as omeprazole, lansoprazole, rabeprazole and esomeprazole, etc.) or H2 receptor antagonists (ranitidine or other similar drugs) are often used, with the proton pump inhibitors having the best effect. (3) Gastric motivational drugs: if there is gastric emptying obstruction can be used domperidone, etc.. If the effect of the acid suppressant alone is not good, the addition of pro-gastric motivational drugs can be ineffective. Surgical treatment requires more than 3 months, usually 2 to 4 weeks to show the effect. If the above treatment is not effective, we should consider whether the drug dose and the course of treatment are sufficient, or whether there is a compound cause. If necessary, consult the relevant specialist to discuss the treatment plan, most of the severe reflux patients who failed surgical treatment, anti-reflux surgical treatment can be effective, due to post-operative complications and recurrence and other achievements, should strictly control the indications for surgery.