Patients with coronary artery disease who still have panic attacks with medication should further check electrocardiogram or 24-hour ambulatory electrocardiogram, echocardiogram, coronary CTA or coronary angiogram if necessary to understand the condition in detail and adjust the treatment plan. Coronary artery disease is an atherosclerotic heart disease, in which lipid deposits in the intima form plaques that block blood vessels, causing myocardial ischemia or necrosis and clinical manifestations of angina pectoris or myocardial infarction. Myocardial ischemia can easily stimulate sympathetic excitation, which can cause increased heart rate and arrhythmia, and patients will feel panic and chest tightness. Taking beta-blockers, such as metoprolol tartrate or bisoprolol fumarate, can effectively relieve the symptoms of panic. If you still have panic symptoms after taking the medication, consider that the dosage of beta-blocker is insufficient, and then gradually increase the dosage. The heart rate is controlled at 55-70 beats/min and the coronary blood flow increases, the panic symptoms will be improved significantly.