Urine protein is more common in patients with kidney disease, and many patients also find themselves with the problem of urine protein during the examination, so how harmful is urine protein? The appearance of urine protein is often a manifestation of kidney function problems. Patients who find urine protein must be examined to clarify its causes and timely treatment. The accumulation of serum proteins in the glomerular thylakoid membrane can be observed in the renal failure model, and the aggregation of these macromolecules in the thylakoid region can cause thylakoid cell damage, proliferation and increased synthesis of each thylakoid matrix, resulting in glomerulosclerosis. In proteinuric nephropathy models, there are low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) Apo B as well as Apo A deposits in the glomeruli These aggregates can also eventually lead to glomerulosclerosis. Second, the toxic effect on proximal tubular cells When proteinuria occurs, the amount of protein entering the renal tubular epithelium increases, which increases lysosomal activity, suggesting that the protein causes lysosomal overflow into the tubular cell plasma, and the subsequent cellular damage can stimulate inflammation and scar formation. Third, changes in tubular cell biology induced by Many of the renal diseases that present with proteinuria have excessive cellular hyperplasia, representing a nonadaptive response that leads to renal failure. There is increasing evidence that proteins can directly modulate tubular cell function, altering their growth characteristics and their cytokine and matrix protein phenotype expression, which can lead to the release of PDGF, FN and MCP-1 from the basal side of the tubule and induce the fibrotic process. Fourth, cause tubular interstitial hypoxia aggravated protein urine reabsorption each digestion of a large amount of protein requires extra energy, can cause tubular cell hypoxia, so as to cause tubular cell damage Through the above introduction, we have a better understanding of the dangers of urinary protein, then how to prevent the appearance of urinary protein in life? The prevention methods of urine protein A, dietary improvement For the people with high pressure of life and work, it is best to eat clean, easy to digest, fresh vegetables, fruits, low fat, low sugar, and moderate amount of water. Avoid mutton, spicy, stimulating, seafood, beef and other foods. Second, prevention of infection For patients who have developed urine protein, it is important to avoid the occurrence of infection, like colds, trauma need to be actively prevented. Third, rational use of drugs In the absence of a will to avoid drug abuse, kidney disease patients are prohibited butamycin, streptomycin, gentamicin and other nephrotoxic drugs. Prohibit the use of aristolochic acid drugs such as cyanide and mucuna pruriens.