Embryonic arrest refers to the death of the embryo or fetus has been retained in the uterine cavity has not been naturally discharged, can be divided into two categories, the first is the fertilized egg did not develop buds, color ultrasound after 7 weeks of gestation still did not see the fetal buds but only see an empty fetal sac, and the second is that there was a development of fetal buds but soon after the arrest of death, ultrasound results of the fetal sac has buds but the development of the development of the fetal sac is significantly behind the gestational weeks, and at the same time there is no fetal cardiac tube pulsation, the size of the fetal sac in line with the weeks of gestation or atrophied. Deformation. In Chinese medicine, embryonic abruption can be categorized as “fetal leakage” or “restlessness of the fetus”. Jiyin Zangmu: “Fetal movement and fetal leakage are both associated with the discharge of blood; while fetal movement is associated with abdominal pain, fetal leakage is associated with no abdominal pain.” Fetal leakage refers to a woman’s vaginal bleeding in small amounts from time to time after pregnancy, which may be sporadic or sporadic and not accompanied by abdominal pain; while fetal restlessness refers to a woman’s abdominal pain or abdominal distension after pregnancy, or accompanied by small amounts of vaginal bleeding. Embryo termination not only jeopardizes the physical health of pregnant women, but also causes irreparable psychological trauma to the patients and their families, therefore, the research on the prevention and treatment methods of embryo termination has been emphasized by the majority of scholars of Chinese and Western medicine. Through the comparative study of the prevention and treatment methods of Western medicine and traditional Chinese medicine, we aim to have a comprehensive understanding of this disease and further reduce the occurrence of embryonic arrest. 1, the western medical prevention and treatment methods of embryonic sterilizations 1.1 Anatomical abnormalities, including uterine anomalies, Asherman’s syndrome, cervical insufficiency, uterine fibroids, affecting the uterine blood supply and the intrauterine environment, resulting in abortion. According to the different anatomical abnormalities, the corresponding surgical treatments are chosen. 1.2 Genetic abnormalities The incidence of chromosomal abnormalities in patients with embryonic arrest is reported to be 4.8% to 10.8%, which is recognized as one of the basic causes of embryonic arrest. There is no effective treatment for chromosomal abnormality-induced embryonic arrest, and only prenatal genetic counseling and diagnosis are available 1.3 Infectious factors Lawton et al. found that Mycoplasma and Chlamydia can cause cervical mucosal epithelial lesions, leading to intrauterine infections, which can lead to an increase in toxicity of the developing embryo and impair the integrity of the fetal membranes, and thus cause the development of the embryo to cease. Patients with a history of embryonic arrest should be tested for TORCH or cultured for pathogens prior to pregnancy to exclude appropriate pathogenic factors. 1.4 Environmental influences can be summarized as physical factors (radiation, etc.), chemical factors (organic solvents, drugs, ionizing radiation, etc.), and bad habits (smoking, drinking alcohol, excessive coffee consumption, etc.). Patients with a history of embryo termination should avoid exposure to these three factors during a second pregnancy. 1.5 Immunological abnormalities Homozygous immune miscarriage is caused by an abnormality in the immune tolerance mechanism at the mother-fetus interface, in which the embryo is attacked by the maternal immune response, resulting in rejection of the embryo, and is mainly treated with leukocyte immunotherapy, which stimulates the production of sufficient closed antibodies in patients who have suffered miscarriages. Studies have shown that after 3 to 5 sessions of leukocyte immunization, the patient’s level of closed antibody and its unique type of antibody increases significantly. Patients with autoimmune miscarriage can usually detect various antibodies, such as antiphospholipid antibodies (APA), antinuclear antibodies (ANA), antithyroid antiperoxidase antibodies, etc., and can be treated with immunosuppressive therapy. 1.6 Endocrine abnormality Luteal insufficiency (LPD), prolactin (PRL) elevation, polycystic ovary syndrome (PCOS), thyroid disease, etc. are important endocrine factors causing embryonic abortion, which can affect the function of hypothalamus – pituitary – ovary axis, mainly manifested as abnormal secretion of progesterone and its metabolites, thus causing early abortion, accounting for about 23% ~ 67%. Luteal insufficiency is due to insufficient production of progesterone or luteal maintenance time is too short, endometrial dysplasia or endometrial maturation delayed for more than 2 d, preventing the pregnant egg and embryo development and cause miscarriage, the clinic generally need to increase the body’s content of luteinizing hormone through oral luteinizing hormone capsule or intramuscular injection of HCG and luteinizing hormone injections to achieve the role of fetal preservation. ② Polycystic ovary syndrome patients, pregnancy with metformin treatment, the miscarriage rate is significantly reduced. ③ Pituitary gland function abnormality or occupational lesions, can cause hyperprolactinemia, inhibit hypothalamic gonadotropin synthesis and release, cause follicular development and ovulation obstacles, and interfere with fertilization and embryonic development, resulting in the cessation of embryonic development. There is still controversy about whether to discontinue bromocriptine after pregnancy in patients with hyperprolactinemia. For patients with prolactin microadenomas, if bromocriptine is discontinued after pregnancy, bromocriptine should be reviewed every 2 months, and bromocriptine treatment should be restarted in case of headache and visual impairment. ④ In patients with abnormal thyroid function, such as those with hypothyroidism, thyroxine or levothyroxine sodium should be used, while those with hyperthyroidism should have their hyperthyroidism controlled before they become pregnant, and changes in their condition should be closely observed during pregnancy. 1. 7 Pre-thrombotic state Easy thrombosis, also known as hypercoagulable state of blood, refers to the easy coagulation state of blood produced by increased concentration of coagulation factors, or decreased concentration of coagulation inhibitors, which has not yet reached the degree of thrombus generation, or a small amount of thrombus formed is in the state of dissolution. The antiphospholipid antibody syndrome has been well studied, and it has been affirmed that it is associated with early and midterm fetal loss. The general view is that hypercoagulability changes the blood flow status in the uteroplacental area, which is easy to form local microthrombus, or even placental infarction, so that the blood supply to the placenta decreases, and the embryo or fetus becomes ischemic and hypoxic, which leads to poor development of the embryo or fetus and miscarriage. Low molecular heparin (LMWH) alone or in combination with aspirin is the main treatment at present. The usual dose of LMWH is 5,000 U subcutaneously twice daily. Dosing begins in early pregnancy. In more advanced cases or in patients who have not used aspirin prior to conception, the drug should be started before ovulation. It has been reported that aspirin alone is not as clinically effective as low molecular heparin alone or in combination 1.8 Low levels of leptin and nuclear hormone receptors have been studied extensively in recent years and have been suggested to be a risk factor for embryonic abruption. Yoon et al. have shown that leptin plays an important role in the regulation of metabolism and reproduction, and that leptin modulates Gn-RH release through the JAK-STAT signaling pathway, inducing pituitary LH and LDH release, and inducing pituitary LH and LDH release. Henson et al. identified leptin receptor transcription factors in chorionic and extrachorionic trophoblast cells, and low levels of leptin appear to be associated with miscarriage. Thus leptin and its receptor have the potential to serve as markers of embryo viability in early pregnancy. However, the exact mechanism of its role in embryonic arrest and its treatment is not yet well understood and further research is needed. 1. 9 Psychological factors Emotional stress puts the body in a state of stress, destroying the original stable state and causing neuroimmune and endocrine disorders in the body, especially changes in progesterone. The level of progesterone in the body decreases, and the embryo develops poorly, resulting in fetal sterilizations. Therefore, pregnant women should pay attention to regulate the emotional state, avoid excessive mental tension 2, modern research on the prevention and treatment of foetal termination Modern Chinese medicine treatment of foetal leakage, foetal restlessness, etc., more in the inheritance of ancient theories on the basis of innovation and become. The main treatment methods include traditional Chinese medicine (ancient prescription, self-proposed prescription), proprietary Chinese medicines, external application, acupuncture and so on. 2.1 Traditional Chinese medicine 2.1.1 Shouyu Pill: From Zhang Xichun (张锡纯), “醫医衷中参西錄” which says, “The fertility of boys and girls depends on the kidneys for its strength,” so Shouyu Pill was established. It consists of Cuscuta, Sambucus, Schizandra and Colla Corii Asini. Modern pharmacological studies have found that the main effects of Shou Yu Wan include inhibition of uterine smooth muscle contractile activity, enhancement of luteinizing function of the pituitary ovary, and estrogenic and progesterone-like activities. Acute toxicity, long-term toxicity and reproductive toxicity studies on Shou Zi Wan showed no significant toxic side effects when taken orally. Clinical studies have shown that the formula of Shou Yu Pill: 30 g of Cuscuta chinensis, 15 g of Radix et Rhizoma Gastrodiae, 10 g of Sambucus nigra, 12 g of Cortex Eucommiae, 20 g of Radix Rehmanniae Praeparata, 12 g of Colla Corii asiatica, 15 g of Radix et Rhizoma Ginseng, 12 g of Rhizoma Atractylodes Macrocephala, 6 g of Radix et Rhizoma Gonorrhoeae, in a total of 35 cases, the cure rate was 25 cases, accounting for 71%; the improvement rate was 9 cases, accounting for 26%, and the non-cure rate was 1 case, accounting for 3%, with an effective rate of 97%. Angelica sinensis: from “The Essentials of the Golden Chamber? It consists of 5 herbs: Angelica sinensis, Scutellaria baicalensis, Paeonia lactiflora, Rhizoma Ligustici Chuanxiong and Rhizoma Atractylodis Macrocephalae. Laboratory studies have demonstrated that the aqueous extract of Angelica sinensis has a significant inhibitory effect on the contraction of isolated uterine smooth muscle in rats. Clinical studies showed that 28 cases were cured out of 30 cases (96.7% cure rate) and 2 cases were invalid. Studies have shown that Th1 cytokine IL-12 was significantly higher in the early preterm miscarriage group than in the normal early pregnancy control group; Th2 cytokine IL-4 showed a significant decrease, and IL-12/IL-4 was significantly higher than in the normal pregnancy group of the same gestational week before treatment, and was significantly reduced to the level of the same gestational week of the normal pregnancy after the treatment of “An Dian Er Tian Tang”. After treatment with “An Dien Er Tian Tang”, IL-12/IL-4 decreased significantly and reached the level of normal pregnancy. Therefore, it is inferred that the formula of “An Dian Er Tian Tang” has good clinical efficacy in tranquilizing the fetus. Clinical studies showed that there were 40 cases in the treatment group, of which 31 cases were cured, 5 cases were improved and 4 cases were invalid, with an overall effective rate of 90%. 2. 1. 2 Self-proposed formula Zi Kidney and Fetus Yuk Pill: Contemporary famous doctor Prof. Luo Yuankai’s self-proposed formula, the main components are: Codonopsis pilosulae, Radix et Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis Macrocephalae, Radix et Rhizoma Alba, Radix Polygoni Multiflori, Radix et Rhizoma Polygoni Multiflori and Radix Rehmanniae Praeparata. Experimental studies have shown that this formula has the effect of promoting the development of follicles and corpus luteum and improving the blood supply to the ovaries and uterus of the test rabbits [18]. The endometrium of the test rabbits after the use of the drug was mildly thickened, the number of glands increased significantly, and most of them showed different degrees of secretory changes, and the individual animals had the formation of red and white bodies, and therefore it is often used in the luteal insufficiency of the first trimester of miscarriage. Kidney Nourishing and Fetal Tranquilizing Drink: A formula prepared by Guo Rong, Chief Physician of Obstetrics and Gynecology Department of Hubei Provincial Hospital of Traditional Chinese Medicine, consisting of 15 g of Morus alba, 30 g of Semen Cuscutae, 15 g of Eucommia, 15 g of Cortex Eucommiae, 20 g of Astragalus, 12 g of Rhizoma Atractylodis Macrocephalae, 6 g of Scutellaria baicalensis, 12 g of Colla Corii Asini, and 6 g of Licorice. Clinical studies showed that 14 patients in the treatment group were cured, 12 cases with obvious effect, 5 cases with effective effect and 4 cases with ineffective effect, with a total effective rate of 88.57%, which significantly improved the clinical symptoms and signs of the patients, especially in the improvement of abdominal pain or swelling, lumbar soreness and distension, and nocturnal urinary frequency. 2.2 Proprietary Chinese medicines In the treatment of patients with fetal leakage and fetal restlessness, proprietary Chinese medicines follow the method of regulating the Chong Ren, tonifying the kidney and stabilizing the fetus, combining with the specific conditions of the patients, applying pills, powder, cream, and dan types of proprietary Chinese medicines in the treatment of symptoms, and the clinical studies have proved that the therapeutic effect is remarkable, as follows. Anzi Combination: Composed of Chuanjie, Sangsheng, Cuscuta, Ramie root, Danshen, Scutellariae, Atractylodes Macrocephalae, Radix et Rhizoma Glycyrrhizae, Glycyrrhiza Uralensis and so on. Studies have shown that Anzi Combination is clinically effective in the treatment of preterm miscarriage and not only can it significantly improve the clinical symptoms such as abdominal pain, lumbar soreness, vaginal bleeding and so on, but it can also promote the growth of pregnancy hormones, and can also maintain the smooth decline of hormones when the fetus is shaped, so that it guarantees normal development and improves the quality of the embryo. It can promote the growth of pregnancy hormones and maintain the steady decline of hormones when the fetus is formed, thus ensuring the normal development of the embryo and improving the quality of the embryo. Pregnacare oral liquid: according to the famous Chinese medicine and gynecology family in Anhui Dangshan Yang’s gynecology ancestral secret recipe “to protect the fetus without worrying about the formula” developed by the national three new drugs, consisting of Codonopsis pilosula, Astragalus membranaceus, Chinese yam, Colla Corii asiatica, dog’s spine, Cuscuta chinensis, Cuscuta sinensis, Cortex Eucommiae, Eucommia, Atractylodis Macrocephalae, Ramie Roots, Ailanthus, and so on. Clinical studies showed that of the 303 cases in the treatment group, 295 cases were cured and 8 cases were invalid, with a cure rate of 97.4%. Experimental studies have shown that Pregnacare has obvious fetal preservation effect on experimental abortion in rats caused by acupuncture and uterotonin, has obvious relaxation effect on isolated uterus of rats and mice and in vivo uterus of rabbits, and can antagonize the excitatory effect of uterotonin and acetylcholine on the uterus. Pill for Kidney Tonicity and Fetal Tranquilization: It is composed of Prepared Polygonum multiflorum, Semen Cuscutae, Radix Rehmanniae Praeparatae, Rhizoma Atractylodis Macrocephalae and Rhizoma Atractylodis Macrocephalae, and is a new drug of the third class of Chinese medicine. Clinical research shows that the cure rate of the treatment group is 90.8% and the cure rate of the control group is 79.1%, the difference is statistically significant. After treatment, it can significantly improve the clinical symptoms of patients, and progesterone and other indicators increased significantly. Clinical research shows that the total effective rate of the experimental group is 97.5%, and the total effective rate of the control group is 82.5%. Fertility-preserving spirit capsule is better than progesterone. 2. 3 Other 2. 3. 1 external application of the Liwan District Hospital of Traditional Chinese Medicine in Guangzhou, research shows that through the free decoction of Chinese medicine particles applied to the umbilical cord for the treatment of preeclampsia, the therapeutic effect is obvious, in which the treatment group of 30 cases, 18 cases cured, 6 cases of apparent effect, 4 cases of effective, ineffective 2 cases, the total effective rate of 93.3%. The formula for the cuscuta, sequestra, mulberry parasol, mugwort leaves, through the stimulation of drugs on the umbilical cord, stimulate the meridian qi, dredge the meridians, and harmonize qi and blood. 2. 3. 2 Acupuncture famous acupuncture master Mr. Xie Xiliang that the uterus point is outside the meridian point, yinjiao point is the Chong Ren and Shaoyin kidney meridian of the meeting point, Fushe point Department of the Taiyin spleen meridian, syncope yin liver meridian and the yinwei vein of the meeting, the three points with small moxa moxibustion, a total of warming the uterus, replenish the blood, benefit the effect of qi, the uterus get blood nourishment, get the qi of the full, the fetus is self-fixed.