Embryonic arrest refers to the cessation of embryonic development in early pregnancy due to some reasons. ultrasound examination shows that the buds or fetus in the gestational sac are not well formed, without fetal heartbeat, or the gestational sac is withered. Clinically, it belongs to the category of miscarriage or stillbirth. There are many reasons for embryonic sterilizations. (1) endocrine disorders: the early development of the embryo, need three important hormone levels, one is estrogen, one is progesterone, one is human chorionic gonadotropin, as the mother, their own endogenous hormone is insufficient, can not meet the needs of the embryo, may result in the embryo’s sterilization and miscarriage. The most common is luteal insufficiency, which can cause delayed endometrial development and short luteal phase, thus affecting the implantation of the fertilized egg, or early pregnancy abortion. Luteal insufficiency is often accompanied by other glandular function abnormalities, such as hyper or hypothyroidism, diabetes, androgenism and hyperprolactinemia, etc., these factors are not conducive to the development of the embryo, and miscarriage is closely related. (2) Immune factors: common autoimmune diseases are systemic lupus erythematosus, scleroderma, mixed connective tissue disease, dermatomyositis and so on. The second one is the problem of reproductive immunity, if we carry some kind of antibody ourselves, it may affect the development of embryo. In fact, the testing of antibodies is not the same in every hospital, and the doctors’ viewpoints are not the same either. From our research point of view, we believe that there are four influencing factors, one is anti-sperm antibodies, which, if they are to be present, may resist sperm-egg binding; secondly, it is anti-endometrial antibodies, which, if they are present, may affect the development of the embryo, and resist the development of the embryo; and thirdly, it is anti-ovarian The third is anti-ovarian antibody, which will affect the quality of the egg; the fourth is called anti-chorionic gonadotropin antibody, which is an important hormone that should be secreted seven days after the union of sperm and egg, but if one has this kind of antibody, it will resist the secretion of the hormone, which may cause the embryo to stop. (3) Abnormalities of the uterus: The internal environment is the lining of the uterus, if it is too thin or too thick, it will affect the implantation. Miscarriage due to uterine defects accounts for about 10-15%, commonly (1) congenital abnormalities of the Mullerian ducts include unicornuate uterus, bicornuate uterus and bicornuate uterus resulting in a narrow uterine cavity and restricted blood supply. Abnormal development of uterine arteries may lead to asynchronous metamorphosis and abnormal implantation. (2) Uterine adhesions, mainly caused by uterine trauma, infection or placental tissue residue after the uterine cavity adhesions and fibrosis. It hinders normal metamorphosis and placental implantation. (3) Reduced blood supply due to uterine fibroids and endometriosis leading to ischemia and venous dilatation, asynchronous metamorphosis, abnormal implantation, and hormonal changes caused by fibroids can also cause pregnancy failure. (4) Congenital or injurious endocervical laxity and abnormal cervical development due to intrauterine treatment with ethinyl estradiol often lead to miscarriage in mid-term pregnancy. (4) Chromosomal problems: Chromosomal abnormalities can also lead to early miscarriage if the embryo does not develop. Chromosomal abnormalities include quantitative and structural abnormalities, quantitative abnormalities can be divided into aneuploidy and polyploidy, the most common abnormal karyotype is triploidy, and trisomy 16 accounts for 1/3 of the total, often lethal. 25-67% of trisomy 21, 4-50% of trisomy 13, and 6-33% of trisomy 18 are bound to miscarry. Others are haploid (4SX), tetraploid due to abnormal cleavage resulting in embryo failure. Structural abnormalities include deletions, balanced translocations, inversions, overlaps and other closures. Balanced translocation is the most common chromosomal abnormality. Current research on chromosomal problems suggests that chromosomes pair, swap, and separate to form gametes, which combine to form a syncytium. If there is an abnormality in one of the haplogroups, it results in the inability to develop normally, which can lead to miscarriage, stillbirth, stillbirth, and malformation of the child; therefore, prenatal diagnosis is required to prevent the birth of a chromosomally affected child. For chromosomal abnormality carries caused by miscarriage, fetal arrest, etc. At present, Western medicine has no effective treatment, only can carry out prenatal genetic counseling and diagnosis. In the case of chromosomal abnormalities, there is a theoretical chance of delivering babies with normal karyotypes and carriers, and prenatal diagnosis of these couples will ensure the birth of normal babies. Of course, current research has also shown that couples with normal chromosomes may have chromosomal abnormalities during gamete formation and embryo development. For example, if a woman is older than 35 years old, her eggs are aging and prone to chromosome non-separation, resulting in chromosomal abnormalities; semen abnormalities, such as macrocephaly, most of the spermatozoa are diploid, and the formation of polyploid embryos after fertilization leads to miscarriage. Adverse environmental influences such as toxic chemicals, radiation, high temperature, etc. can also cause chromosomal abnormalities in embryos. Therefore, the key to prevent chromosomal abnormalities leading to abortion is to regulate the body of both husband and wife, so that the normal coordination of the functions of the internal organs, the balance of yin and yang, the choice of the best and pregnancy, and away from the adverse environment. (5) Reproductive tract infections: In addition to the above factors, the infection caused by early pregnancy abortion is getting more and more attention from scholars at home and abroad. Severe TDRCH infection in early pregnancy can cause embryonic death or miscarriage, and less severe infection can also cause embryonic malformation. Studies have shown that cytomegalovirus can cause premature abortion and intrauterine fetal death. After maternal infection, pathogens can be carried through the bloodstream and infect the placenta, causing damage to the chorionic villous membrane and capillary endothelium, destroying the placental barrier, and the pathogens enter the fetus, leading to miscarriage, embryonic arrest, and fetal malformations. In recent years, many studies have shown that mycoplasma infection is related to embryonic arrest, and the positive rate of mycoplasma infection in cervical secretions of women with embryonic arrest is significantly higher than that of normal women, and there is a highly significant difference. (6) Environmental factors: physiological changes during pregnancy, the mother’s body to the absorption, distribution and excretion of therapeutic drugs and various environmental harmful substances have changed greatly, in the early stage of development, the embryo is extremely sensitive to the effects of therapeutic drugs and environmental factors, at this time, a variety of harmful factors can lead to embryonic damage, or even loss. Many drugs and environmental factors are important factors causing early embryonic death or fetal malformation. Environmental hormones can act directly on the central neuroendocrine regulatory system, causing reproductive hormone secretion disorders, reduced fertility and abnormal embryonic development. There are various environmental factors that cause miscarriage, including physical factors such as X-rays, microwaves, noise, ultrasound and high temperature, as well as heavy metals such as aluminum, lead, mercury and zinc, which affect the implantation of the fertilized egg or directly damage the embryo and lead to miscarriage. Various kinds of chemical drugs, such as dichloropropane, carbon disulfide, anesthetic gases, oral antidiabetic drugs, etc., can interfere with and damage the reproductive function, resulting in miscarriage, stillbirth, deformity, developmental delay and dysfunction of the embryo. Adverse lifestyle habits such as smoking, alcoholism, coffee, drugs and certain medications all affect early embryonic development.