On an empty stomach or after a meal? For aspirin enteric tablets, the instructions say to take them before meals. Why is this? Aspirin enteric tablets are acid-resistant but not alkali-resistant, and the tablets are covered with an enteric film. Its outer film is mainly composed of cellulose, silicon or other inactive materials, which can resist the acid environment in the stomach and decompose only in the alkaline environment in the duodenum, thus avoiding damage to the gastric mucosa. If taken after meals, food relieves the acidic environment in the stomach, the acidity of gastric juice increases, and the drug is easily dissolved; in addition, the tablets are mixed with food to prolong the residence time of the drug in the stomach, which also tends to destroy the enterolysis film and increase the chance of drug dissolution in the stomach. When taken before meals, the drug is not easy to dissolve because of the strong acidic environment in the fasting stomach, and the gastric emptying speed is fast after taking it, so the residence time in the stomach is short, so the damage to the gastric mucosa can be reduced. Therefore, we suggest that this product should be taken before meals for better effect. Morning or evening? From a physiological point of view, many physiological activities of the cardiovascular system are characterized by circadian rhythms. Studies have found that the high incidence of cardiovascular events is between 6-12 am, and that platelets are more active in the early morning, and that enteric or extended-release aspirin takes 3-4 hours to reach its peak after oral administration. Therefore, it has been suggested that aspirin at bedtime may better inhibit early morning platelet function if the daily morning dose does not provide optimal protection during the high event time. However, there are no randomized controlled clinical studies that can confirm that bedtime aspirin administration reduces cardiovascular events. In addition, some studies have suggested that bedtime aspirin may be helpful in lowering blood pressure.