Pharmacological treatment for atrial fibrillation includes ventricular rate control, resetting and maintenance of sinus rhythm, and anticoagulation. The choice of specific regimen needs to be considered by the physician according to the patient’s heart condition and the degree of atrial fibrillation, and it is best to choose the most suitable medication for you. The treatment of atrial fibrillation includes medication, electrical cardioversion and catheter radiofrequency ablation. The goals of drug therapy include symptom relief, ventricular rate control, cardioversion and maintenance of normal rhythm, and anticoagulation. The type and dosage of medication and the need to combine it with other treatments should be selected by a physician according to the patient’s specific situation. Drug therapy to control ventricular rate is an important measure to relieve symptoms and improve cardiac function. Some patients with acute paroxysmal atrial fibrillation may regain sinus rhythm as the ventricular rate decreases. In persistent and permanent AF, the ventricular rate can be controlled at 60-70 beats/min, and the best is not to exceed 90 beats/min for mild activity. The drug of choice is mostly beta-blockers (e.g., metoprolol) or non-dihydropyridine calcium channel blockers (e.g., verapamil), and digitalis (e.g., digoxin) may be used for patients with AF complicated by cardiac insufficiency. Patients with recurrent episodes of paroxysmal atrial fibrillation and a history of persistent atrial fibrillation shorter than one year, with cardiac ultrasound suggesting insignificant atrial enlargement (≤45 mm), and without thrombosis may be considered for conversion to sinus rhythm using pharmacological resuscitation, electrical resuscitation, or catheter radiofrequency ablation. After successful resuscitation, oral amiodarone and other antiarrhythmic drugs should be continued. In addition, patients with atrial fibrillation are prone to thrombosis due to unstable blood flow in the atria and require anticoagulation therapy. Currently, new oral anticoagulants and warfarin are commonly used. When taking warfarin, regular blood tests for the International Normalized Ratio of prothrombin time (INR) are required to determine the appropriate therapeutic effect of the drug. The choice of specific treatment options varies from person to person, and timely consultation to choose the most suitable treatment option for you is the best. Medication for atrial fibrillation is a very important part of atrial fibrillation treatment. The selection of the type and dosage of medication requires a comprehensive assessment of the patient by a professional physician, and it is important not to take medication or change the dosage of medication on your own.