There is no best treatment for multiple nodules after liver tumor resection, which may be caused by inflammation, tumor recurrence and other factors, and can be treated with antibiotic drugs or chemotherapy, surgery, intervention and other methods. 1. Inflammation: If there is inflammation and infection in the liver, it will be manifested as multinodular nodular changes, at this time, it is necessary to use antibiotic drugs for treatment, such as ornidazole and so on. 2. Tumor recurrence: if the liver tumor has recurrence, it will also lead to multinodularity, at this time, it is necessary to carry out surgery, intervention or chemotherapy, targeted therapy and other methods to target the tumor for treatment again. Chemotherapy drugs include fluorouracil, cisplatin and so on, and targeted therapy drugs include lenvatinib, sorafenib and so on. After liver tumor resection surgery, it is necessary to pay attention to regular review and monitor indicators such as methotrexate. If multiple nodules reappear after surgery, it is necessary to consult a doctor in time, complete the relevant examinations, make a clear diagnosis, and adopt appropriate methods of treatment under the guidance of the doctor.