Design and selection of individualized treatment plans for endometriosis (chocolate cysts)

  1.Treatment principle: The treatment plan is designed according to the patient’s age, fertility requirements, symptoms, lesion location and severity, with comprehensive consideration and individualized design.  Those with fertility requirements or infertility due to endometriosis with mild lesions can choose medication first; young patients with severe lesions use fertility preserving surgery.  Younger patients with severe disease who do not have the requirement of reproduction can choose ovarian function preserving surgery.  For older patients with severe disease who have already had children, radical surgery can be chosen.  2. Treatment options: Expectation (follow-up): Patients with mild endometriosis can be followed up and observed.  Pain relief: Patients with endometriosis often have dysmenorrhea, which can be fertilized with non-steroidal anti-inflammatory drugs (anti-inflammatory pain, ibuprofen), or common painkillers (disulfiram), etc. Severe dysmenorrhea is often ineffective.  Hormonal drugs: Short-acting contraceptives: such as Mafulon, Dain 35, etc., inhibit ovarian function and the growth of the endometrium and ectopic lining. The usual course of treatment is 3-6 months.  Progestin: also known as pseudopregnancy therapy. Commonly used drugs include Gynoquinone tablets, which inhibit ovarian function and the growth of endometrium and ectopic endometrium. The usual course of treatment is 3-6 months.  Danazol: Also known as pseudo-menopause therapy, it is a testosterone derivative that inhibits the release of gonadotropins from the pituitary gland, closes the ovarian function and inhibits the growth of the endometrium. The usual course of treatment is 3-6 months.  Progesterone (endometrium): a testosterone derivative that counteracts estrogen and progesterone and inhibits the growth of the endometrium. The usual course of treatment is 3-6 months.  GnRH-a: also known as pharmacological trend (ovariectomy), commonly used drug Daphylline, inhibits pituitary secretion of gonadotropins, inhibits ovarian function and suppresses the endometrium.  Surgical treatment: Purpose of surgery: to remove endometriosis and relieve symptoms.  (1) Indications for surgery: Patients with the following conditions can be considered for surgery Drug therapy is ineffective or the condition is aggravated.  Ovarian chocolate cyst >5cm in diameter Urgent need for fertility Patients with severe endometriosis CA125 and other tumor-related indicators are elevated, suggesting active growth of endometriosis and also a high-risk factor for endometriosis malignancy, so the surgical indications can be relaxed and the time of surgery can be appropriately advanced Recurrent endometriosis after surgery (2) Surgical techniques Laparoscopic surgery: Currently menstruation is used as the preferred mode of treatment for endometriosis. Main advantages: minimally invasive surgery and thorough removal of endometriosis lesions.  Caesarean section: traditional surgery.  (3) Surgical modality Fertility preserving surgery: Removal of endometriosis lesions in the pelvis, including chocolate cysts, with preservation of the uterus and ovaries.  Sacral nerve block: young patients who choose to preserve fertility and have severe dysmenorrhea can undergo sacral nerve block.  Surgery to preserve ovarian function: for patients under 45 years of age with severe endometriosis, removal of the uterus and fallopian tubes, removal of pelvic endometriosis lesions, and preservation of both, or one, or part of the ovaries can be considered.  Radical surgery: For patients over 45 years old with severe endoheterosis, surgical removal of the uterus, ovaries and fallopian tubes to remove the foci of pelvic endoheterosis.  Preventive measures: Menstrual health care: endometriosis is thought to be caused by the backflow of menstrual blood into the pelvic and abdominal cavities. Menstrual blood carrying endometrial fragments flows backwards through the fallopian tubes into the pelvic and abdominal cavities, where the endometrium becomes viable and grows under certain conditions, forming endometriosis. Therefore, menstrual health care is very important. During menstruation, you should avoid vigorous activities, sex, cold diet, stimulating diet, etc. Avoid surgical operations: uterine operations such as abortion and curettage can lead to endometriosis into the abdominal cavity and cause endometriosis.  Contraceptive pills: Contraceptive pill use can reduce the occurrence of endometriosis.  Recurrence of endometriosis after surgery: The recurrence rate after endometriosis surgery is high. The causes of recurrence are related to a variety of factors, among which surgical factors are closely related, involving the surgical method and the quality of surgery. Patients with conservative surgery (preserving fertility and ovarian function) can be treated with medication for 3 months after surgery, which is helpful below reducing recurrence. Patients who wish to have children should obtain a pregnancy as early as possible after surgery. Pregnancy itself can inhibit the growth of the endometriosis lesion and reduce recurrence. Patients with failed natural pregnancy or no possibility of natural pregnancy can use assisted reproduction techniques, such as artificial insemination, IVF, etc. From the perspective of postoperative endoheterosis recurrence, successful pregnancy is a good measure to prevent recurrence.