Male factors cause about 70% of infertility, of which about 60% are due to oligospermia and weak sperm. However, weak spermatozoa have more causes and complex pathogenesis, but the specific treatment has not made much progress and has not yet formed a practical and effective treatment plan, and the clinic mostly adopts integrated treatment measures of Chinese and Western medicine. Modern research has shown that excessive reactive oxygen species in the reproductive system is an important factor causing low sperm motility. Only spermatozoa with an intact membrane structure can ensure the balance of internal and external ion concentration and avoid the attack of immune activated cells and phagocytosis of sperm-specific antigens. Therefore, drugs that can effectively remove excess reactive oxygen species from semen have a positive effect on the treatment of weak spermatozoa. Li Wei et al. found that coenzyme Q10 levels in seminal plasma were positively correlated with sperm motility, which may be due to the fact that higher concentrations of coenzyme Q10 in seminal plasma can effectively inhibit damage to sperm membranes by reactive oxygen species, thus improving sperm motility. Coenzyme Q10 is a human coenzyme Q-like substance with strong antioxidant capacity and specific immune enhancing effects, which not only plays a coenzyme role in the process of cellular energy production, but also plays a protective role when free radicals attack the mitochondrial membrane Safarinejad divided 212 patients with idiopathic oligospermia infertility into CoQ10 treatment group and placebo treatment group, and found that CoQ10 treatment group Infertile patients showed significant changes in sperm concentration and viability as well as the percentage of normal form sperm. Therefore, CoQ10 is beneficial to enhance the antioxidant capacity of the reproductive system, improve sperm motility and sperm quality, and has a certain therapeutic effect on male infertility.