Objective To investigate the clinical efficacy and safety of the high-speed turbodontic drilling method for extraction of mandibular obstructed third molars. The mean operative time, postoperative pain, swelling and restriction of mouth opening, the integrity of the extraction sockets and the incidence of postoperative bleeding, dry socket and other complications were compared between the two groups. The mean operative time, postoperative bone fracture, root fracture and dry socket complications were significantly reduced in the experimental group compared with the control group. Conclusion The high-speed turbodontic drill method is clinically effective and safe for extraction of mandibular obstructed third molars.