Headache is a symptom of novel coronavirus infection. As a newly emerged pathogen, the symptoms of novel coronavirus infection are not identical in different individuals. According to the available case data, while the typical manifestations of novel coronavirus infection are fever, malaise, dry cough, and progressive dyspnea in the majority of patients, a small number of patients have headache as the first manifestation. In addition, a small number of patients have mild symptoms and may even have no obvious fever symptoms. Therefore, patients must undergo formal pathogenetic testing to confirm the diagnosis.