“Purpura nephritis is a common clinical kidney disease. So is it really just an inflammation of the kidney caused by purpura? Today let’s talk about the understanding of Chinese medicine and Western medicine for purpura nephritis!” Western medicine’s understanding of allergic purpura nephritis Allergic purpura nephritis (HSPN) is a self-limiting disease, the diagnosis relies on clinical symptoms and pathological changes, and it is currently considered to occur by the following mechanisms: immune response, clinical evidence and the high recurrence rate of HSPN after renal transplantation demonstrate that HSPN is an immune complex-mediated systemic disease; inflammatory mechanisms, multiple cytokines may be involved in In patients with HSP, platelet aggregation is enhanced, resulting in hypercoagulable blood and even microthrombus formation, and activated platelets secrete platelet-activating factor (PAF), which stimulates glomerular tethered cells to contract, decreases glomerular filtration rate, induces inflammatory cells to infiltrate glomeruli and release multiple inflammatory mediators, induces platelet aggregation, and It promotes thrombus formation, increases glomerular basement membrane permeability, produces proteinuria, mediates the deposition of immune complexes and complement in the kidney, and several aspects act together to cause the disease. Chinese medicine’s understanding of allergic purpura nephritis Chinese medicine has its own unique insight into allergic purpura nephritis, in the purpura stage belongs to the Chinese medicine of “purple spot”, “epistaxis”, “hair spot”, and “grape disease”. In the later stage of the disease, when the deficiency of vital energy occurs, it is similar to “deficiency labor”. In the later stage of the disease, when there is deficiency of vital energy, it is similar to “deficiency labor”. Based on decades of clinical experience, a professor concluded that heat, toxicity and stasis are important features of the symptoms of this disease. In the case of kidney ligament, it is hematuria and proteinuria; as for the deficiency, it is mostly related to deficiency of body, deficiency of endowment or long term disease damage to positive energy. The early stage of the disease is mostly caused by external sensation or food or drug allergy, and it is mostly manifested as wind-heat external attack in those who have the standard evidence, and as heat poison incandescence in those who do not have the standard evidence. If the disease is prolonged, it can be manifested as yin deficiency and fire, qi and yin deficiency, qi deficiency and blood stasis, and qi not taking in blood.