Most nasopharyngeal carcinoma patients in advanced stage are treated with radiotherapy combined with chemotherapy or radiotherapy combined with surgery. Because most nasopharyngeal cancer lesions are more sensitive to radiation therapy, radiation therapy is mostly preferred clinically, but patients with advanced nasopharyngeal cancer, whose cancer tissues are less sensitive to radiation therapy, mostly need to adopt combined radiation therapy and chemotherapy. Advanced patients need to use chemotherapy first to improve the sensitivity of tumor tissues to radiation and use radiotherapy at the same time. For advanced patients with distant metastases, chemotherapy also needs to be used first. For advanced patients with large tumors, chemotherapy should be used first to shrink the tumor to a certain level before radiation therapy. After radiotherapy, patients will be treated with preventive chemotherapy according to the viability or status of tumor cells to avoid recurrence. The combined treatment of radiation and chemotherapy is effective in improving the survival rate of patients for 3, 4 and 5 years after surgery. When the local lesions do not subside or recur in advanced patients after the above treatments, surgery needs to be considered according to the patient’s own situation. If the primary lesion has been controlled in advanced patients but the metastatic lymph nodes in the neck have not regressed after radiotherapy, a combination of a cervical lymph node dissection may be considered.