I. Background In January 2015, the first ultrasound-guided transjugular vein congenital septal defect closure was successfully performed in the Department of Cardiac Surgery of the First Affiliated Hospital of Guangzhou Medical University.On August 6, 2015, we successfully completed the first case of intravenous anesthesia non-tracheal intubation ultrasound-guided transjugular vein cardiac septal defect closure. Second, what are the advantages of atrial/ventricular septal occlusion with adjustable curved sheath via right internal jugular vein? 1.No need for large X-ray equipment, no radiation damage. 2.Operating under ultrasound guidance, the anatomical structure of the heart and the delivery sheath can be clearly displayed. 3.Adjustable curved sheath head end can be adjusted within 0~180°, and by rotating the sheath and moving the depth of the sheath, it can make the head end of the blocking sheath perpendicular to the atrial septal plane and located in the center of the defect. 4.Short delivery path, the sheath enters the defect location directly without using guidewire and sheath core, which will not damage the intracardiac structures. 5.Low bleeding, usually no blood transfusion is needed. The operation time is short, the postoperative hospital stay is short, and almost no scars are left after the operation. 6.The operation is performed in the operating room, and once the blockage fails, the operation can be immediately transferred to extracorporeal circulation, which is a double guarantee.