How to diagnose and treat cough variant asthma

  Cough variant asthma (CVA), also known as variant asthma, heterogeneous asthma, cough asthma, and cryptogenic asthma, is a specific type of asthma. It was named “variant asthma” and has been reported more frequently since then. The clinical features of CVA lack specificity and are easily misdiagnosed, so the diagnosis and treatment of CVA are reviewed below.  Most scholars believe that the pathogenesis of CVA is very similar to that of asthma, with 99-100% of patients showing persistent airway inflammation and airway hyperresponsiveness (AHR), but to a lesser extent than typical asthma, with airway spasms occurring in the uncinate airways, and thus no or little croup is heard, whereas in asthma airway spasms occur in the small airways, often accompanied by intrapulmonary croup. The cough may be related to airway inflammation and airway smooth muscle contraction stimulating the cough reflex receptors, but it is also believed that there is no obvious smooth muscle spasm.  2. Diagnostic criteria: domestically accepted criteria: 1 persistent or recurrent cough >1 month, low sputum, aggravated by exercise, but no wheezing episodes; 2 symptoms occur mostly at night in the morning or at bedtime; 3 seasonal onset or exposure to irritating odors that cause AHR symptoms such as breath-holding and unbearable choking; 4 exclusion of other chronic respiratory diseases; 5 no improvement in symptoms after antibiotic and symptomatic treatment >2 weeks, and anti-allergic and 6 with one or more of the following allergic diseases or medical history: history of allergic rhinitis or allergic dermatitis, increased peripheral blood eosinophils (EOS) or serum IgE >200ug/ml, large amount of EOS found in sputum, positive skin allergen test, and family history of asthma.  Treatment: CVA itself is not life-threatening, but cough symptoms can have a great impact on daily work, study, life and rest. Other anti-inflammatory drugs can also be used for CVA, such as sodium cromoglycate, sodium nedolac, anti-LTs drugs, etc. The principle of treatment for CVA should be mainly anti-inflammatory, supplemented by bronchodilator therapy, and CVA, like asthma, is prone to recurrence, so it is very important and necessary to desensitize and maintain inhaled hormone therapy during the stable period of the disease, and to treat with the original effective program during the attack. At the same time, you should try to avoid dust, smoke, paint, pesticides, cold air and other excitatory factors, do not eat seafood, grasshoppers, bean worms and other foods, and avoid aspirin, benzoin and other drugs that can easily trigger asthma.