The harm of gallbladder wall thickening is mainly determined by the causes that cause gallbladder wall thickening, including cholecystitis, gallbladder cancer, hepatitis, etc., as follows: 1. Cholecystitis: the most common cause of gallbladder wall thickening is cholecystitis, mostly seen in gallbladder stones. Gallbladder inflammation mainly causes patients’ severe abdominal pain, and some gallbladder inflammation, if very serious, may cause suppuration, perforation or even gangrene of gallbladder, which may lead to high fever, chills and jaundice, and in serious cases, infectious shock may occur, endangering patients’ lives. 2. Gallbladder cancer: In some cases, the thickening of gallbladder wall is uneven thickening, which should alert the possibility of gallbladder cancer, which is a very high degree of malignancy Gallbladder cancer is a tumor of the digestive system with a very high degree of malignancy, and once gallbladder cancer appears, the survival of patients will be significantly affected. Currently, it is believed that the five-year survival rate of gallbladder cancer may be around 5%-30%, and patients with advanced gallbladder cancer may die in 3-6 months.3. Hepatitis: Some patients with thickened gallbladder wall do not have clinical symptoms, so they should be alert to whether they have liver lesions, especially hepatitis, mostly seen in hepatitis B and C. Gallbladder wall thickening itself is not particularly harmful, but hepatitis B and C can further lead to liver cirrhosis and even liver cancer.