Non-squamous non-small cell lung cancer refers to non-small cell lung cancer other than squamous cell carcinoma, mainly including adenocarcinoma and large cell carcinoma. Lung cancer can be divided into small cell lung cancer and non-small cell lung cancer according to the histologic type, and non-small cell lung cancer is more common, accounting for about 85% of lung cancer. Non-small cell lung cancer can be further divided into squamous cell carcinoma, adenocarcinoma, large cell carcinoma, adenosquamous carcinoma, sarcomatoid carcinoma and other types. Non-squamous non-small cell lung cancer is the type of adenocarcinoma, large cell carcinoma, and adenosquamous carcinoma except squamous cell carcinoma. Among them, adenocarcinoma is the most common type of lung cancer, which is prone to early local infiltration and metastasis, and mostly occurs in women, with little relation to smoking. Large cell carcinoma is less common, accounting for 10% of lung cancers, and belongs to undifferentiated carcinoma, but it metastasizes at a later stage and has a high chance of surgery. Adenosquamous carcinoma, sarcomatoid carcinoma and lymphoepithelioma-like carcinoma are less common. Non-squamous non-small cell lung cancer has similar etiology with lung cancer, which is mainly related to air pollution, asbestos and other cancer-causing factors, radiation, diet, heredity and so on. It is recommended that patients should consult the doctor in time and choose the appropriate treatment plan according to the specific type of lung cancer they are suffering from.