Possible causes of calf muscle pain include spasm, muscle injury and neuralgia. 1. Spasm: calf muscle cold or low calcium and other spasms will appear pain, pain is more intense, after rubbing, hot compresses can be relieved. 2. Muscle injury: due to strenuous activities, exercise, long walks, etc., resulting in calf muscle, ligament injury, pain can occur, usually after rest can be relieved. 3. Neuralgia: due to lumbar spinal stenosis or lumbar disc herniation compression of the nerve roots innervating the calf, can cause calf pain. There may be other reasons for calf muscle pain, such as deep vein thrombosis, etc., if the improvement is not obvious or aggravated after rest, you should go to the regular hospital in a timely manner, by the doctor according to the symptoms, signs and auxiliary examination to determine the specific cause of the disease to give the correct treatment.