The sudden growth of hard lumps of pain in the skin at the edge of girls’ underwear is considered to be caused by local lymph node enlargement, vestibular glanditis, folliculitis or sebaceous cysts caused by infection. It is recommended to change loose and comfortable underwear and keep the local skin clean and dry. If the pain is severe and the lesions further aggravate, you should go to the hospital: 1. Lymph node enlargement: too tight at the edge of the underwear or rough fabric, repeatedly rubbing the skin can cause local damage, which can cause infection leading to lymph node enlargement and the formation of hard lumps. The inflammatory factors stimulate the patient to produce painful sensations, tenderness is more obvious, it is recommended to do routine blood tests at the hospital, if the blood picture is elevated suggesting bacterial infection, you can take appropriate antibiotics to control the spread of infection, you can also use topical creams, gels, etc., to promote the recovery of lesions as soon as possible; 2, vestibular adenitis: vestibular adenitis is an infectious disease, the pathogens that cause infection mainly include endogenous pathogens (such as Escherichia coli The main manifestation of this is that the vulva will be red, swollen, feverish and painful. The treatment of vestibular adenitis is mainly medication and surgery, medication is under the guidance of the doctor to take or topical antibiotic drugs (such as metronidazole, levofloxacin, etc.), surgical treatment will abscess incision and drainage, the specific treatment is recommended to consult a doctor before deciding; 3, folliculitis: the most common in Staphylococcus aureus infection, causing local redness, swelling, heat and pain, with papules or pustules performance. This causes hard lumps. If the inflammation spreads, it can involve the deep tissue of the hair follicle and develop into a boil, when the pus is not obvious, the papule can be hard and painful to touch, topical antibiotics can be used locally, and when the inflammation is obvious, oral medication can be taken as prescribed by the doctor; 4. The prognosis is good, and antibacterial drugs can be used in case of complicated infection.