Many people with Parkinson’s disease are easily fatigued, and this fatigue is different from the fatigue that used to occur after occasional exertion when the disease was not present; it is constant and difficult to relieve by rest. Fatigue is the most common non-motor symptom of Parkinson’s disease. Parkinson’s disease-related fatigue is an unexplained feeling of energy failure caused by excluding medications, or other physical or mental illnesses, and usually lasts for a period of time, accompanied by reduced vitality, inability to recover from rest, and limitations in daily activities. What are the characteristics of Parkinson’s disease fatigue? Fatigue is a subjective experience that is often described by patients as a state of extreme mental or physical fatigue, weakness, lack of initiative, or even exhaustion. Parkinson’s disease fatigue can be divided into two main categories: central fatigue and peripheral fatigue. Central fatigue has both physical and mental fatigue components and is manifested by difficulty initiating or maintaining mental or somatic activity in the absence of organic damage to the motor system. Physical fatigue manifests itself as a lack of ability to generate power autonomously during exercise. Mental fatigue, on the other hand, manifests itself as an irresistible feeling of exhaustion, lack of energy, and exhaustion. In some patients, fatigue symptoms are not simply associated with symptoms of tremor, stiffness, or involuntary movements; depression, anxiety, apathy, or sleep disturbances can also cause fatigue. Motor fatigue is associated with Parkinson’s disease motor dysfunction. Motor fatigue is peripheral fatigue, where fatigue follows repeated muscle contractions. This fatigue can be improved by anti-Parkinson’s disease medications. Cognitive fatigue is the lack of ability to perform tasks that require the use of the brain, the inability to sustain attention, and the feeling of fatigue. Those with Parkinson’s disease who have impaired cognitive function and encounter brain-challenging tasks have more pronounced symptoms of fatigue. How can fatigue symptoms be improved or relieved? Some patients are fatigued due to some other disorders such as depression, anxiety, apathy, sleep disorders, etc., which need to be treated by other medical means. Other small ways to help relieve the symptoms of fatigue: 1, at home, let family members give more support, share more household chores, do some chores themselves; 2, try and stick to some hobbies, arrange daily activities to help avoid feeling fatigue during the day; 3, you can try to exercise, no matter what causes fatigue, exercise seems to be the only universal effective method, many patients say After moderate exercise, they feel energetic instead. For exercise fatigue, commonly used anti-Parkinson’s disease drugs due to can improve motor symptoms or have a certain role; some patients are due to some depression, anxiety, apathy, sleep disorders and other diseases that cause fatigue, need to be treated by other medical means.