AIDS patients can develop a runny nose. AIDS, also known as acquired immunodeficiency syndrome, is a chronic infectious disease caused by human immunodeficiency virus infection, which eventually leads to immune deficiency and clinical death from various infections. Therefore, AIDS patients with respiratory infections such as respiratory viruses or bacteria may have a runny nose. Usually antibacterial drugs or antiviral drugs can be given for symptomatic treatment, while local nasal sprays can be used to relieve the symptoms of nasal mucosal congestion and edema. In addition, we should pay attention to the patient’s diet and increase nutrition to improve the resistance to the disease, so that the disease can be relieved.