The metastasis of pancreatic neuroendocrine tumors is usually related to the degree of differentiation, human immunity and blood supply, and not much related to the size of the tumor. 1. Degree of differentiation: pancreatic neuroendocrine tumor is a kind of rare malignant tumor, the metastatic speed is usually related to the degree of differentiation of the tumor, the tumor cells are generally divided into low differentiation, medium differentiation, high differentiation, generally the lower the differentiation the easier it is to metastasize. 2. Human immunity: the metastatic speed of the tumor is also related to the immunity of the patient. Usually, if the patient’s physical condition is better, the slower the metastatic speed of the tumor is, and the worse the physical condition is, the easier the metastatic situation is. 3. Blood supply: the better the blood circulation in the lesion, the faster the metastatic speed of the tumor, because the blood flowing out of the lesion will be mixed with some tumor cells. The more blood flows out of the affected area, the more likely to cause tumor metastasis. Patients who are diagnosed with cancer must be treated in time to avoid the aggravation of the condition and metastasis.