Segmental inflammatory lesions of the small intestine are usually treated with medication and diet. Segmental inflammatory lesions of the small intestine is a chronic non-specific inflammatory disease of the digestive tract, mostly associated with intestinal infections and dysbiosis, while smoking, oral contraceptives, diets high in refined sugars, and nutritional deficiencies also increase the prevalence of the disease. There is a lack of a cure for the disease. Clinical treatment is usually a combination of medication and dietary therapy to control disease activity and maintain remission. Amino-salicylic acid preparations, such as sulfasalazine, mesalazine, etc., can be taken according to the doctor’s instructions. These drugs can control the disease and reduce the inflammatory reaction, and the appropriate drugs can be used according to the specific conditions and the doctor’s instructions. Improve the diet structure, eat less spicy and stimulating food, eat more food rich in dietary fiber and easy to digest, quit smoking and drinking, keep a good mood, avoid overwork. Segmental inflammatory lesions of the small intestine are generally more common in the age of 20 to 40 years old, and should be actively prevented from complications while being treated. Gastrointestinal discomfort symptoms should be timely medical treatment, to avoid delay and aggravation of the condition.