Early-onset epileptic encephalopathy: This refers to persistent epileptic activity in the neonatal period or infancy, which leads to neurological sequelae such as cognitive and motor global developmental lags, mental retardation, and autism. Unlike the mature brain, these patients often have microcephaly, brain atrophy, and a poor prognosis because the persistent epileptic activity affects the structure, synaptic plasticity, and neural loop formation of the early developing brain, which can lead to stagnant development of brain structure and function. Early epileptic encephalopathies include Otawara syndrome, infantile spasms, severe myoclonic epilepsy in infants, early myoclonic encephalopathy, non-progressive myoclonic encephalopathy, and severe focal wandering epilepsy in infants. Adrenocorticotropic hormone (ACTH) is used preferentially in patients with infantile spasms. 2.stiripentol. preferentially used in patients with tuberous sclerosis with infantile spasms. 3. hormonal therapy 4. ketogenic diet 5. other antiepileptic drugs: keplar. preferentially in early infantile epileptic encephalopathy and migrating partial seizures in infancy.