With the accelerated pace of life in modern society, people’s habits and diet structure has changed a lot, the incidence of constipation is increasing, but many people do not take it too seriously, most of the symptoms when the purchase of their own drugs or take health products “autonomy”. Reminder, occasional constipation, under the guidance of doctors, short-term drug treatment is not a big problem, but if long-term indiscriminate use of stimulant laxatives, will produce serious drug dependence, the dosage of drugs will become increasingly large. In particular, some laxatives on the market and intestinal tea contains a compound called “anthracene”, long-term use can lead to colon melanosis, increasing the risk of colon polyps and colon cancer. Xiao Liu is 29 years old, working for a foreign company, although high income, good working environment, but the workload is relatively heavy, and often subjected to intense work pressure. 2 years ago she found that she began to constipation, first 2 to 3 days a line of stool, and later developed to 4 to 5 days a time, and the face is becoming increasingly unattractive, face often acne, and even began to grow spots. Miss Zhang nervous, asking around to see if there is a rapid solution to constipation medicine, after listening to a friend introduced to take a few months of “often run tea”, constipation has indeed improved. But I did not expect that after a few months, Miss Zhang found that even if the daily drink laxative tea does not work. And, in addition to constipation, she also often perceived a significant sense of foreign body in the anus, the heart is very uneasy. When she went to the hospital, she was advised to do a colonoscopy, and it was found that her colon mucosa had become dark. Miss Zhang was startled and was worried that this lesion would induce bowel cancer. In fact, Xiao Liu is a typical patient with colonic melanosis caused by long-term laxative use. In fact, some laxatives (such as rhubarb, senna) and intestinal tea contains a compound called “anthracene”, the human body if taken for a long time, will lead to a large number of pigments deposited in the intestinal mucosa, so that the surface of the colon becomes black, known as colonic melanosis. Colon melanosis is a non-inflammatory disease with lipo-brown pigmentation of the colonic mucosa, and the detection rate is between 0.06% and 5.9%. The occurrence of colonic melanosis is due to the fact that constipation itself is a factor in the development of colonic melanosis, and the second is the use of laxatives due to constipation, especially long-term use of anthraquinone-based laxatives, which can lead to the occurrence of colonic melanosis. Studies have shown that the fecal toxins produced by prolonged retention of feces in the colon during constipation can stimulate the intestinal wall to induce apoptosis and be engulfed by phagocytes together with tissue fragments, which are then converted into lipofuscin and deposited in the lamina propria of the intestinal mucosa, which can make the intestinal mucosa darken. Anthraquinone laxatives can also induce apoptosis of colonic mucosal epithelial cells, resulting in the deposition of lipofuscin in the lamina propria, causing the intestinal mucosa to turn black. If long-term constipation, coupled with the use of anthraquinone laxatives, it is like “adding insult to injury”, greatly increasing the incidence of colonic melanosis. Clinical data show that the incidence of colonic melanosis in patients with constipation who take anthraquinone laxatives continuously for less than 1 year is more than 80%, and the incidence of colonic melanosis in patients with constipation who take the drug intermittently for more than 1 year is about 70%. Therefore, the main point of colon melanosis prevention is to prevent constipation, and to prevent long-term use of laxatives, especially to take less anthraquinone laxatives. Although colon melanosis is a benign, there is an increased risk of colon polyps and colorectal cancer. As long as you stop taking laxatives, through reasonable treatment and good lifestyle habits cultivation, as soon as possible to form a regular bowel movement, normal bowel cleansing, colon mucosa melanin deposition no longer deepen, you can gradually improve. With the accelerated pace of life in modern society, people’s habits and dietary structure have changed greatly, and the incidence of constipation is increasing day by day. Constipation mainly refers to the reduction in the number of bowel movements, reduced stool volume, dry stool, and straining to defecate, generally every 2 to 3 days or longer to defecate once, or less than 3 times a week. Numerous studies have proven that mental and psychological problems such as stress, anxiety and depression may trigger or even aggravate the symptoms of constipation. What are the ways to improve constipation and prevent colonic melanosis in daily life? Reconstructing bowel habits: If constipation is caused by lifestyle reasons, it is best not to use laxatives or corkage because it may interfere with the normal intestinal reflexes, but to have regular bowel movements after breakfast after a fixed period of time even without bowel movements. If the long-term application of laxatives or corkage patients should not suddenly stop using, but temporarily choose a safe laxative. Improve diet: 1. adequate portions of diet, because constipation is often caused by eating small amounts of food. 2. appropriate volume or residue of food. For constipation caused by painful spasms such as internal hemorrhoids, anal fissures, and perianal abscesses due to anal sphincter spasm, it is not necessary to have coarse food, but smooth or soft food. 3. Stimulation of fruits and vegetables. For the abdominal muscle, anal muscle or intestinal smooth muscle weakness caused by lack of bowel power constipation of the old, malnutrition, abdominal viscera prolapse, vegetables, fruits effective. Such as grapefruit, dragon fruit, celery. 4. Drink enough water so that the intestines get enough water to facilitate the passage of intestinal contents. In addition to food containing liquid, 6-8 glasses of water daily is generally sufficient. Drink a cup of hot boiled water half an hour before breakfast, there is a mild laxative effect. Third, exercise. Appropriate physical activity is necessary, the tension of the abdominal muscle helps defecation, large abdominal stool should strengthen the abdominal muscle calcination. Fourth, biofeedback therapy for constipation. Biofeedback therapy is an important behavioral treatment method commonly used in clinical practice. During the treatment, the doctor uses a bioreceptive probe with data display, puts the probe into the patient’s anorectum, and instructs the patient to increase abdominal pressure, forceful defecation, or do anal rapture training and other actions according to the feedback data on the instrument, and adjusts the training content and intensity through the change of data, and finally achieves to improve the coordination of intestinal movement and anal contraction of the constipated person, and helps him/her to defecate spontaneously. This treatment is non-invasive, easy to tolerate, and avoids the adverse effects of drugs, and some patients in the clinic have greatly improved their symptoms after treatment.