1, the initial treatment phase: propylthiouracil or methimazole monthly dosage corresponding to 300-400mg or 30-40mg, the dosage of more serious cases, 3 times divided, every 8 hours, after 2-3 weeks, the clinical performance if no improvement should increase the dosage, but generally not more than 60mg per day. If the symptoms are still obvious after 3 months of treatment, the dose should be checked for interfering factors. 2.Drug reduction phase: When the symptoms are significantly reduced, weight is increased, heart rate is reduced to 80-90 times per minute, T3 or T4 is close to normal, the dose can be reduced once every 2-3 weeks according to the condition, each time by 5mg. Normal and stable, gradually transition to the maintenance phase, generally takes about 2 to 3 months. 3. Maintenance phase: The daily dosage is 5-10 mg, which can be further reduced to 2.5-5.0 mg before discontinuation for a period of about 1-1.5 years. Throughout the course of treatment, it is important to avoid intermittent dosing. In case of stress such as infection or psychological factors during any phase, it is advisable to increase the dosage at any time and then decrease it after stabilization. The dose should be reduced only when TSH is high and T3 and T4 are low, so as to improve the cure rate. Otherwise, it is easy to relapse.