Generally, there are no cancers with sore legs as the first symptom, so it is impossible to make a judgment of the disease based on this single symptom. Some cancers in the middle or late stage may have sore legs with tumor infiltration and metastasis. However, in most cases, other factors are mostly considered to cause leg soreness. It is recommended to seek medical consultation at regular hospitals in time to identify the causes and treat them in time: i. Physiological factors: leg muscle strain will cause leg soreness, which is common in people who are not good at exercise. Suddenly a lot of exercise causes tissue damage or lactic acid accumulation, and most of them will occur leg muscle weakness, soreness, swelling and pain. In addition, mental tension or overexertion can also cause patients to have sore legs, weak patients can also have sore legs, some patients can be accompanied by cold extremities, back pain, dizziness, tinnitus and other symptoms, usually can be relieved after rest and massage. Second, pathological factors: 1, common diseases: common diseases have leg diseases, such as rheumatoid arthritis, femoral head necrosis, osteoarthritis, etc., will cause leg acid due to inflammatory reaction. Patients with anemia or chronic lung disease may cause ischemia and hypoxia in the leg muscles and symptoms of leg soreness, while patients may also have symptoms such as fear of cold and tinnitus. Patients with diabetes and varicose veins in the lower extremities often have symptoms of sore legs because of obstructed blood return or circulation in the lower extremities. Patients with abnormal thyroid function can have sore legs due to metabolic abnormalities. In addition, hypocalcemia, hypokalemia, lumbar disc herniation, etc., may also cause sore legs, which need to be dealt with after perfecting relevant examinations and clarifying the causes; 2. Cancer: commonly there are liver cancer, stomach cancer, intestinal cancer, which may cause wasting, weakness and signs of malnutrition due to disease consumption, and patients mostly feel weakness and sore legs, which need to be treated by surgery, together with radiotherapy and chemotherapy, etc. Pay attention to strengthen nutrition, consume more high-protein food, eat less and more meals to enhance physical fitness and improve the symptoms of sore legs, and if necessary, parenteral nutrition can also be performed. Pelvic tumors such as ovarian cancer, cervical cancer, etc., which compress the nerves can also cause sore legs and need to be treated by surgery with postoperative radiotherapy and chemotherapy. In addition, if bone metastasis occurs in lung cancer, breast cancer and prostate cancer, leg pain will also occur. For tumors occurring in bone and soft tissues, the symptoms of leg pain are not obvious in the early stage, but may develop into persistent pain in the later stage, at this time, leg pain is no longer an early symptom, but a symptom of advanced cancer, which needs to be dealt with after the cause is clear.