Allergic purpura is an allergic systemic necrotizing small vasculitis, and the kidney capillaries are the most abundant, the glomerulus is composed of capillary collaterals, so allergic purpura is prone to kidney injury. From the pathological point of view, more than 90% of patients with allergic purpura have altered renal pathology, only there are light and heavy, about 30%-60% will appear clinical symptoms (hematuria or/and proteinuria, etc.) Zhai Wensheng, Department of Pediatrics, The First Affiliated Hospital of Henan College of Traditional Chinese Medicine
The pathological basis of allergic purpura is the immune reaction leading to systemic small vasculitis, the blood is in a hypercoagulable state, when the kidney is involved, the glomerular capillary blood micro thrombus formation, and with the glomerular capillary wall and thylakoid IgA-based immune complex deposition, the pathological manifestation of proliferative nephritis with thylakoid hyperplasia as the main. Therefore, in clinical practice, we use western medicine to suppress abnormal immune drugs and anticoagulants, and Chinese medicine to activate blood circulation and remove blood stasis.