In the early stage of severe acute pancreatits (SAP), due to the activation of pancreatic enzymes, necrosis of the pancreas and peripancreatic tissues, changes similar to “chemical burns” occur in the abdominal cavity, and a large amount of fluid leakage leads to the accumulation of fluid in the abdominal cavity. This in turn affects the stability of the patient’s respiratory and circulatory functions and plays an important role in the progression of the disease. Therefore, timely and effective drainage of intra-abdominal fluid, reduction of peripancreatic exudation, restoration of gastrointestinal function as soon as possible, and effective control of infection are of great significance in improving the prognosis of severe acute pancreatitis. the methods of drainage of abdominal fluid in SAP patients include open surgery, laparoscopic drainage and percutaneous puncture drainage. Although open drainage is adequate, it is traumatic, and the second blow of surgery may aggravate the occurrence of SIRS and increase the incidence of abdominal infection and medically-derived injury. At present, it is only applied to some patients with extensive necrotic exudate in the abdominal cavity and viscous necrotic infected tissues that are not easily drained minimally invasively. Although the laparoscopic anterior and posterior approaches to drainage are less traumatic than open drainage, the surgical blow can still aggravate the damage of these important organs for those patients with combined heart, lung, kidney and other organ dysfunction. Our department adopts the method of ultrasound-guided, early percutaneous peritoneal tube placement and drainage for the treatment of severe acute pancreatitis, and receives better clinical results. Ultrasound or CT-guided percutaneous peritoneal puncture and drainage can be performed under local anesthesia, which has the advantages of small trauma, simple and easy operation, and simultaneous drainage at multiple points. Guidewire-guided percutaneous peritoneal tube placement is less invasive than small abdominal incision placement.