Blistering of the lips is not a manifestation of AIDS, but is usually caused by the herpes simplex virus, which can be treated by applying acyclovir ointment to achieve antiviral treatment. There are three major features of AIDS manifestations in the oral cavity: first, there are linear red spots, located at the edge of the gums. Second, there is Candida albicans infection, usually on the tongue or buccal mucosa, and the doctor will help diagnose it when you go to the hospital. Third, Kaposi’s sarcoma, Kaposi’s sarcoma is relatively rare and occurs in the late stage of AIDS patients. For lip blisters, it can be basically ruled out to be related to AIDS. After the blistering of the lips, the patient must promptly carry out nutritional support, and at the same time with the antiviral treatment, about 7-14 days will be healed.