For the diagnosis of rheumatoid arthritis, the patient should first have symmetrical small joint swelling and pain, often with swelling and pain in the wrist, proximal interphalangeal joints and metacarpophalangeal joints. The diagnosis of rheumatoid arthritis can be clarified if the patient has the above clinical manifestations, and there is an increase in inflammatory index, blood sedimentation, C-reactive protein, as well as positive rheumatoid factor, anti-CCP antibody and anti-AKA antibody. Once the diagnosis of rheumatoid arthritis is confirmed, patients should be treated with the immunosuppressants methotrexate and leflunomide as soon as possible.