Heart disease caused by hypothyroidism can be treated with medications levothyroxine, nitroglycerin, and isosorbide mononitrate. Hypothyroidism can have an important effect on the heart. Long-term hypothyroidism can cause swelling of the heart muscle cells and slow down the conduction speed of the heart, and the patient will have symptoms such as tightness in the chest, weakness, and slowing of the heart rate. It can be relieved and treated by the drug nitroglycerin, isosorbide mononitrate and other vasodilating drugs. The cardiac manifestations of hypothyroidism itself can be corrected with thyroid hormone therapy if there is no comorbid organic heart disease. Patients with hypothyroidism should be given replacement therapy such as the drug levothyroid hormone to correct hypothyroidism and improve myocardial metabolic disorders. Starting from the smallest dose and gradually increasing to the dose of complete replacement, slow heart rate, heart block and pericardial effusion caused in hypothyroidism can be relieved in most of the patients after thyroid hormone replacement therapy. When hypothyroidism causes heart disease, it is necessary to go to the regular hospital in time to check the cause of the disease, under the doctor’s advice to carry out targeted treatment, follow the doctor’s instructions to use medication, not unauthorized use of medication.