Temporomandibular joint disorder syndrome usually does not heal on its own. Without treatment, its symptoms will occasionally disappear, only to recur after a period of time. Temporomandibular joint disorder syndrome is the most common disease of the oral and maxillofacial area, including masticatory muscle disorder disease, structural disorder disease, joint inflammatory disease, and osteoarticular disease, etc. The pathogenesis is not fully understood and may be related to psychosocial factors, immune factors, and joint anatomical factors. In the clinic, the treatment plan varies according to the patient’s different symptoms. Psychotherapy is mainly used to reduce the patient’s stress state and physical therapy is used to relieve the symptoms. Patients with temporomandibular joint disorder syndrome have complex manifestations and various clinical treatments. Once suffering from this disease, patients should seek professional medical consultation as soon as possible in order to obtain better results and ensure quality of life.