Splenic purpura is one of the clinical symptoms of hepatic purpura. The majority of patients with hepatic purpura are asymptomatic, a few can show liver enlargement and mild transaminase elevation, occasionally accompanied by splenic purpura need to be distinguished from infectious purpura and drug purpura. 1, Infectious purpura The purpura occurs secondary to various infectious factors that damage the capillary blood wall. Therefore, this purpura is not an independent disease, but a clinical phenomenon of various infectious diseases. During the development and progression of the disease, in addition to purpura, the patient also has fever, chills and clinical symptoms related to the site of infection. 2, drug purpura Aspirin, anti-inflammatory pain, allopurinol, heavy metal salts, phenothiazines, sulfonamides, penicillin, quinine and coumarins can cause skin purpura, which will disappear automatically after stopping the drug. In addition to drug immune complexes that damage small blood vessels and increase the fragility of blood vessels, the pathogenesis is partly related to drug inhibition of platelet production, drug antibodies that increase platelet destruction and drug interference with platelet function. It should be distinguished from infectious purpura and pharmacological purpura, which are characterized by no certain site, non-symmetrical, and not in batches. The latter purpura is characterized by scattered small dots or flakes, no tendency to fuse, not protruding from the skin surface, and asymmetric distribution.