Nedaplatin, also known as Nedabo, N254-S, or NDP, has a molecular formula of C2H8N2O3Pt and a molecular weight of 303.18. Mechanism of action and pharmacokinetics: NDP is a 2nd generation platinum compound synthesized in Japan. NDP has been shown to be more sensitive to kill non-small cell lung cancer than small cell lung cancer in vitro using human non-small cell lung cancer and small cell lung cancer cell lines. and carboplatin, and its efficacy was higher than or equal to that of cisplatin and significantly higher than that of carboplatin when compared with life extension and chemotherapy index. Pharmacokinetic studies in humans showed a biexponential profile of total plasma platinum concentrations when NDP was administered at 80-100 mg/m2. The kidney is the major excretory organ, and urinary excretion rates were 40%-69% over 24 hours with 80-100 mg/m2 IV dosed for 60 minutes. When administered for 5 consecutive days, 73.1%-100% of the administered amount is excreted in urine within 1-6 days. Indications】For non-small cell lung cancer, small cell lung cancer, head and neck cancer, esophageal cancer, ovarian cancer, cervical cancer, bladder cancer, testicular tumor. Usage】 Dissolve 80-100mg/m2 in saline at least 300ml each time, drip intravenously for more than 60 minutes, and rehydrate 1000ml after the drip, once every 4 weeks. Adverse effects】 1. Myelosuppression is a dose-limiting toxicity, manifested as leukocyte and platelet reduction. Severe leukocytosis and thrombocytopenia were 21.1% and 28.5% respectively. 2. Gastrointestinal reactions: 74.9% showed varying degrees of nausea and vomiting, and a few (5.7%) showed diarrhea. 3. Renal function impairment; a few people showed elevated blood BUN and Cr (4% for Bao Bao and 7% for Li) and reduced creatinine clearance (be careful with 7%). 4. Others: Tinnitus, hearing impairment, peripheral neurotoxicity and abnormal liver function (ALT, AST elevation) in 3% of cases. Very few have allergic manifestations. Precautions】 1. This drug should be dissolved in saline or 5% xylitol injection for intravenous drip. 2.Use as soon as possible after dissolution. 3.After the infusion is finished, 1000-1500ml of fluid should be rehydrated. 4.Avoid extravasation of the drug, otherwise it will cause local tissue sclerosis and necrosis. Clinical summary】 Nedaplatin is a 2nd generation platinum compound with a broad anti-tumor spectrum and good efficacy in a variety of solid tumors, its gastrointestinal reactions and nephrotoxicity are lighter than cisplatin, but bone marrow inhibition is more obvious than cisplatin.