I. Overview vitiligo is a common and frequent pigmented skin disease, the disease is characterized by local or generalized pigment loss, forming white spots. It is an acquired, limited or generalized skin pigmentation disorder, is a common skin disease affecting beauty. It is easy to diagnose and difficult to treat. It is easy to diagnose and difficult to treat. The Chinese medicine is called “vitiligo” or “white barge”. The actual fact is that you can find a lot of people who are not able to get a good deal on a lot of things. The actual fact is that you will be able to get a lot more than just a few of these. The actual fact is that you will be able to get a lot more than just a few of these. The so-called skin pigment is skin melanin. Cutaneous melanin is found in melanocytes in the skin and hair follicles. Melanin produced by melanocytes is converted to dopa (DoPa) by tyrosinase enzyme, and then produced through a series of complex biochemical processes. When this process is impaired (e.g., a decrease in copper (cu++) or an increase in sulfhydryl (—SH) in the tyrosinase enzyme in melanocytes), the tyrosinase activity decreases or even disappears, followed by a decrease in melanin production and disappearance, which is usually called depigmentation in medicine. The disease occurs all over the world, with the highest incidence in India and about 12 million people in China, the disease can affect all races, and there is no significant difference in the incidence of men and women. The incidence of the disease has been increasing year by year in recent years, causing widespread concern. What are the reasons for the increasing incidence? How to prevent it? Can it be cured, recurrence and heredity after treatment?
The reason for this is not very clear, there are nine factors: genetic factors; psycho-neurological factors; chemical factors; tyrosinase, copper ion relative lack of factors; infection factors; trauma factors and so on. It can be seen that the onset of vitiligo factors are multifaceted, but a considerable number of patients can not find any triggering factors. We found that vitiligo patients, no matter what part of the body they develop, are related to microcirculation disorders. We focus on improving microcirculation when researching therapeutic drugs. According to clinical observation, the causes of this disease are mainly the following.
1, industrial pollution: pollution caused by industrial discharge to the environment is one of the reasons for the increase in incidence in recent years. Industrial production of untreated emissions, wastewater, and the rapid growth of motor vehicle emissions contain many harmful substances, such as sulfur dioxide, strong acids, strong alkalis, lead, arsenic, mercury, benzene, phenol and other chemical or heavy metal toxins can directly cause harm to the human body. In recent years, it has been found that a large number of fluorine refrigerants have been emitted to destroy the ozone layer in the atmosphere, resulting in excessive ultraviolet radiation to the surface of the earth, which can cause harm to humans. All of the above factors are the reason for the increased incidence of skin diseases.
2, agricultural pollution: excessive use of chemicals in crops, such as insecticides, fungicides and ripening agents, etc., excessive feeding of meat and poultry growth hormone residues in the body after slaughter, can cause adverse effects on human health.
3, small foods and beverages small foods and beverages have an obvious impact on the physical development and health of children, the reasons for which are.
1) interfere with the normal eating pattern of children, small food and beverage sweet and delicious, children will do it as a snack to eat at any time, for a long time can not be normal meal according to time, disrupting the normal eating pattern.
2) Long-term use of injury to the spleen and stomach: snack food and drinks are mostly sweet food, Chinese medicine believes that the long-term use of sweet products will lead to stomach heat stagnation, decreased appetite, and even anorexia, paranoia. Long-term paranoia leads to inadequate nutrient intake, malnutrition and reduced immunity, which affects the normal development of the body, and can lead to many diseases.
3) Some small foods that do not meet health standards can contain many chemical additives, such as coloring agents, preservatives, sweeteners, etc. can cause direct harm to children’s bodies.
Researchers have found that some toxic substances, when absorbed, may also cause direct damage to melanocytes by inhibiting the activity of certain enzymes in the body and making melanocyte synthesis impaired. From the current incidence in various countries, it can be seen that the pollution of the environment and food has a greater relationship with the disease, with high population density and high incidence in developing countries, with India ranking first in the world, followed by China and Japan, with a lower incidence in Western developed countries. China’s heavy industrial cities, oil-producing areas, coastal areas have a significantly higher incidence.
4, endocrine and immune dysfunction: certain pathogenic factors (chemical and heavy metal toxins) lead to immune dysfunction, endocrine imbalance, the production of anti-melanocyte antibodies, resulting in melanocyte damage, loss and morbidity. The damaged melanocytes can release antigen again, stimulating the body to produce more anti-melanocyte antibodies, so that more melanocytes are destroyed, thus forming a vicious circle, leading to further development of the disease. The human immune response is a complex physiopathological process. In addition, long-term psychological stress, trauma can also lead to imbalance in the body’s neurohumoral regulation, endocrine disruption and morbidity.
5, trace element deficiency: trace elements are active substances involved in the middle of the body’s metabolism, such as copper, zinc, selenium, iodine, etc., they are directly involved in the synthesis of melanocytes, and the role of protecting melanocytes from heavy metal toxicity damage. Studies have proven that micronutrient deficiency and disproportion can lead to melanocyte synthesis disorders.
6, neuropsychiatric factors: the rhythm of modern life makes some people psychologically overburdened, businessmen, every encounter with poor business and anxiety; workers, sometimes worried about unemployment and worry; organ staff, because of interpersonal relations and promotion and overthinking. Although some people are broad-minded, strong psychological capacity, but encountered a huge blow of unexpected events, beyond the limits of psychological tolerance, will also fall into the bitterness. Long-term psychological stress and mental overstrain can lead to endocrine disorders, immune dysfunction and morbidity. In addition, long-term overload of work pressure, irregular night life and bad habits, so that the body is often in a state of excessive fatigue is also a cause.
7, genetic factors: clinical observation, only a few cases are related to genetics, but does not affect the treatment of the disease.
9, trauma: burns, burns, knife stab wounds, mosquito bites, infections after the formation of skin white spots. The trauma is the triggering factor, is on the basis of the muscle qi and blood and the onset.
Clinical manifestations (1) confined: single or clustered white spots, varying in size, confined to a certain area.
(2) Sporadic: scattered, multiple white spots, often symmetrically distributed, the total area of white spots does not exceed 50% of the body surface area.
(3) Pancytosis: Mostly developed from sporadic, the white spots fuse with each other into irregular large areas and involve more than 50% of the body surface area, sometimes only small islands of normal skin color remain.
(4) extremity: white spots first occur in the extremities of the body, such as the face, hands, feet, toes and other parts, and mainly distributed in these parts, a few can be accompanied by generalized white spots of the body.
The so-called progressive stage means that the skin lesions are expanding, and there are new lesions, positive isomorphic reaction (is trauma or other skin disease based on the formation of new white spots). Stable stage means that the lesions are no longer expanding and there are no new lesions. Clinically, drugs must be selected according to the clinical stage, if improper medication can cause lesion expansion and aggravation, for example, in the progressive stage, it is not advisable to use topical nitrogen mustard alcohol and other more irritating drugs, because it can cause isomorphic reaction and white spot expansion.
The incidence of this disease is 0.5-1%, the incidence of colored people is higher than white people, male and female incidence is not significantly different, any age can develop, some reports as early as 1 day after birth, about 50% of patients before the age of 20 years, any part of the body skin can occur vitiligo.
The clinical manifestation of the skin local pigment loss, produce white spots, and then gradually expand spread, vitiligo disease is not painful, but erosion of the patient’s healthy skin and mind, serious damage to people’s appearance, frustrated people’s spirit, affect normal life, marriage, work and social, is one of the world’s persistent skin diseases.
The melanocyte implantation method has the following three main features:
Fast and efficient: melanocyte implantation method can improve skin photosensitivity by planting melanocytes, stimulate melanocyte recovery function, rapid promotion of skin melanin granule cell regeneration in the short term; adjust the body’s immune and neuroendocrine, blood circulation, improve blood microcirculation.
The effect is remarkable: melanocyte implantation method directly in the white spot area planted melanocytes, skin awakening, after receiving treatment, the patient’s affected skin progressive process, to red, to crimson, to dark brown transformation, a course of treatment, can be transformed to normal skin.
The melanocyte implantation method planted melanocytes through the patient’s large white spot area, combined with advanced treatment instruments to activate the skin basal layer of the pigmented black granular cells, so that they repair, divide and proliferate, secrete melanin, and dendritic protrusions transported to the skin base after the epidermis emanates to the epidermal papillae hair follicles, to truly achieve the effect of preventing relapse.
(2) Quadruple therapy (1) the use of high-performance laser emitted a specific spectrum and light sensitizers combined to promote the growth of pigment cells to restore the color of the lesion.
(2) For lesions that have lost the ability to regenerate pigment cells, “self-cell transplantation” is used in combination with drugs, and healthy melanocytes are planted into the lesion area with advanced equipment made in the United States to make up for the pigment.
The “vitiligo quadruple therapy” has changed many shortcomings of the past treatment methods, with the advantages of targeted, quick results, low cost, painless treatment, highlighting its actual efficacy and treatment standards, relieving the patient’s worries and becoming a typical modern skin therapeutics.
(C) medication is generally still used topical medication treatment compound kalizarin tincture, white spot Kang and vitiligo net. The effect is generally more ideal, if not good enough to inject immunomodulators or oral immunomodulatory drugs.
The latest treatment method of vitiligo: oral medicine plus topical medicine treatment at the same time combined with spiritual guidance, also known as the triple therapy oral medicine: preferred tribulus terrestris whitening pill.
(d) vitiligo nutritional treatment 1, try to avoid taking vitamin C, eat less or do not eat vegetables and fruits rich in vitamin C. Such as green pepper, tomato, citrus, grapefruit, etc.
2, eat copper-rich food, if the body copper ion content increased, melanin production also increased. Therefore, you should eat more snails, mussels, arks and other copper-containing foods.
3, black fungus, kelp, sea cucumber, celery, eggplant, toon teeth, walnut, snapper, amaranth, leek, hair, black rice, elm leaves have the effect of preventing vitiligo, can often eat. Avoid eating strawberries, prunes, sour and spicy food and chicken, sheep and other hairy things.
4, usually eat more food containing tyrosine and minerals, such as meat (cattle, rabbit, pork lean meat), animal liver, eggs (eggs, duck eggs, quail eggs), milk (milk, yogurt), fresh vegetables (radish, eggplant, kelp, etc.), beans (soybeans, peas, green beans, soy products), peanuts, black sesame, walnuts, raisins, snails, clams and other shellfish food.
(E) Chinese medicine: nourish the liver, so that the kidney energy to restore, revitalize the vital energy, such as vitiligo Fu Zheng San and other drugs. The other side can be treated with immunomodulators together, the cure rate is higher.
（The advantages of the five types of quadruple therapy are mainly in the accurate typing and comprehensive dialectical treatment of vitiligo disease.
2. Comprehensive treatment.
①Surgical treatment, more rapid. The five types of quadruple therapy apply the most advanced cutting-edge treatment equipment, using the principle of high-tech specific wavelength narrow-spectrum light wave irradiation, inhibit phagocytosis, promote skin melanocyte regeneration, at the same time, internal Chinese medicine combined with vitiligo physiotherapy, so that capillary expansion, so that the liquid penetrates into the deep layer of the skin, stimulate the formation of melanocytes, accelerate local blood circulation, so that the white spots disappear, for longer history, larger area It has obvious effect on patients with longer history, larger area, end of limbs and patients who do not get any effect from various medications. The instrument treatment is convenient and quick, no side effects, better than a single drug treatment and other characteristics. Generally patients use about a month white spots gradually disappear.
The actual fact is that you can find a lot of people who are not able to get a good deal of money. The five types of quadruple therapy classify the patient’s physique into qi-blood incompatible type, liver-kidney deficiency type, silt-blood blockage type, damp-heat type, and liver-depression-qi stagnation type. For example, liver depression and qi stagnation type patients along the liver meridian spread, white spots to oval more, often with the patient’s emotional changes and development, the drug to dredge the liver and Qi, to activate the patient’s body tyrosinase activity as a supplement, qi and blood through the white spots eliminated.
Six, daily health care 1, comply with medical advice: on time, according to the amount of medication, do not change the dose or time to take medication. In the treatment may encounter unexpected circumstances, such as cold, trauma, allergies, etc., should keep in touch with the treating doctor in order to actively and correctly deal with. Vitiligo treatment should show improvement in 15 days to 30 days, if the expected effect does not appear, you should contact with the treating doctor in time to adjust the treatment method under the doctor’s guidance. Therefore, during the treatment period, the treating physician will meet with you once every half month to observe the changes in your condition in detail. If the road is far away can not be on time face-to-face consultation, should every 1 to 2 months to take a photo for the doctor to observe.
2, daily mentality: vitiligo patients due to the mental burden and psychological pressure is heavy, in life there is not as good, not smooth, more likely to lose confidence and the courage to live on than healthy people. Therefore, vitiligo patients should pay attention to the cultivation of psychological quality, learn to adjust to abnormal emotions, lift the heart conflicts and pressure, which is to personal work life and early wellness.
(1) vent the heart pent-up frustration.
(2) develop hobbies.
Through fitness, recreation, study and work to solve the boredom, divert attention.
(3) Do not panic when things go wrong, and treat it steadily and well.
For worries and unhappiness, acknowledge the reasonableness of its occurrence, and then calmly think of ways to deal with it.
(4) Facing reality.
Many people’s worries are caused by high expectations of life, and once these expectations are not realized, worries will follow. Therefore, the correct face reality, not a stubborn, can bend and stretch.
3, vitiligo patients diet note: vitiligo patients blood and white spot parts due to the lack of certain trace metal elements, and the body tyrosinase activity is reduced, affecting the anabolic melanin, thus producing lesions. Therefore, patients should eat more food containing copper, zinc, iron and other metal elements, so that the tyrosinase activity is enhanced, and then the melanin synthesis is accelerated.
(1) usually eat more foods containing tyrosine and minerals, meat (beef, rabbit, lean pork), animal liver, eggs (eggs, duck eggs, quail eggs), milk (milk, yogurt), vegetables (fresh vegetables, and radish, eggplant, asparagus, fungus, kelp, etc.) beans (soybeans, peas, green beans, soy products), peanuts, black sesame, walnuts, raisins, shellfish such as snails and clams.
Basic contraindicated foods.
(1) Avoid eating onion, garlic, fish, shrimp, mutton, bamboo shoots, pickled vegetables, chili peppers, alcohol. It is not advisable to eat spinach, because spinach contains a lot of oxalic acid, easy to make the affected area itchy.
(2) Eat less food containing more vitamin C. The reason is that vitamin C can make the serum copper and serum copper oxidase levels decrease, affecting the activity of tyrosinase, interfering with the synthesis of skin melanin.
(3) cherries Vitiligo patients should not eat more.
The actual fact is that you can find a lot of people who are not able to get a good deal on this.
4, travel attention: often sunshine due to vitiligo occurs because of the influence of genetic, immune, spiritual and other factors, causing local skin and hair follicles within the melanin synthesis disorder. The ultraviolet rays in the sunlight can promote melanin metabolism, so proper sun exposure can make melanocytes transfer to the cortex and make the skin tone deepen, which is beneficial to the treatment of vitiligo. But in the hot summer, the ultraviolet rays in the sunlight can inhibit the metabolism of melanin instead, which is not conducive to the synthesis of melanin, so the sunlight should be avoided in summer.
Seven, prevention 1, reduce the intake of contaminated food, correct partial diet, adhere to the regular meals, develop scientific dietary recipes, maintain the supply of whole nutrients is particularly important for children.
eg: vegetables and fruits should be repeatedly rinsed before consumption, time allows can be soaked in clean water for 15~30 minutes, then rinsed before consumption, fruits that can be peeled should be peeled.
2.Reduce the inhalation of harmful gases, choose a place with fresh air when practicing or exercising in the morning.
3, pay attention to labor protection. Do a good job of labor protection, reduce direct contact with chemical materials, paints and coatings, heavy metal salts harmful substances.
4, pay attention to the pollution caused by housing renovation. Decoration materials contain formaldehyde, ammonia, benzene and other series of toxic substances, its floor tiles, marble also contains radioactive substances, which can cause multi-system multi-organ damage to the human body. Housing renovation should be ventilated for three months after moving in, and to maintain regular ventilation after moving in, environmental monitoring should be done when available.
5, eliminate worries and sorrows, maintain optimism is the most important factor in the prevention and treatment of disease in adults.
(1) Play the subjective positive factors, enhance the psychological tolerance.
(2) Do not want to do what does not meet the objective, and do not do what cannot be done.