Conservative treatment of severe pancreatitis includes fasting and gastrointestinal decompression, fluid replacement, analgesia and antispasmodic, inhibition of pancreatic fluid secretion, nutritional support, and application of antibiotics. 1. Fasting and gastrointestinal decompression: Fasting can reduce the secretion of pancreatic fluid and prevent further aggravation of symptoms, and continuous gastrointestinal decompression can prevent vomiting, reduce abdominal distension, and lower intracranial pressure. 2. Fluid replenishment, prevention and treatment of shock: intravenous fluid replenishment, correction of electrolyte and acid-base balance disorders, improvement of microcirculation, maintaining circulatory stability, preventing shock. 3. Analgesic and antispasmodic: commonly used antispasmodic drugs are scopolamine, atropine and so on. Analgesics choose weak opioids and non-steroidal analgesics, such as codeine, tramadol, indomethacin and so on. Morphine should not be used, it will increase the tension of oddi sphincter, which is not good for prognosis. 4. Inhibition of pancreatic secretion: commonly used proton pump inhibitors such as omeprazole, H2 receptor inhibitors such as ranitidine, etc., but also the use of growth inhibitors and growth inhibitor analogs such as octreotide. 5. Nutritional support: the fasting period mainly relies on complete parenteral nutrition, and enteral nutrition can be chosen after the condition is stabilized. 6. Antibiotic treatment: for those who have infections, antibiotics can be used empirically or in a targeted manner, commonly used drugs such as cefixime and cefoperazone. For patients with severe pancreatitis, they should be immediately sent to the hospital and treated under the guidance of specialized physicians, and the drugs should be applied under the guidance of doctors. The disease is acute and severe, and can be life-threatening if delayed.