How can the differential diagnosis be made in adults who still look like children?

Patients with chronic exertional cervicodorsal fasciocutaneous fibrositis complain of diffuse pain in the neck and back (sometimes including the thoracic back), evident at the medial aspect of both shoulders and at the cervicothoracic junction, characterized by severe pain in the morning, which is relieved after a few minutes or half an hour of activity, but seems to return in the evening due to excessive activity, and improves after rest, similar to hypertrophic spondylitis. How can the differential diagnosis be made in adults who still look like children? The following is the differential diagnosis of adult appearance still like children: 1, cartilage dystrophy: chromosomal dominant inheritance, mainly the long bone epiphysis chondrocyte formation disorder, and affect the length of the bone, so that the bone thickens and does not grow, the affected child limbs are thick and short, but the trunk principal, so the length of the upper body is greater than the lower body, hanging hands but hip, fingers thick and short, each finger flush, low nasal bridge, head circumference is large, forehead prominence, abdominal prominence, anterior lumbar convexity, significant posterior hip convexity, and normal intelligence. X-ray examination of the long bones shows that the long bones are short, with increased curvature and dilated ends. Congenital Foolishness: Also known as Down’s syndrome, it is caused by autosomal abnormalities. The child is often short, with a special face and intelligent backwardness, low nasal bridge, wide distance between the eyes, two eyes outward, mouth half-open, often extend the tongue outside the mouth, hand palm lines often through, short and inward curved pinky, sometimes accompanied by congenital heart disease, chromosomal analysis can determine the diagnosis. 3, mucopolysaccharidosis: by congenital mucopolysaccharide metabolism disorder, so that the body of the tissue cells stored in excess of mucopolysaccharide caused. Normal at birth. The child has a short stature, progressive mental retardation, thick skin, dry hair, wide eye spacing, sunken nasal bridge, large tongue, often accompanied by hearing impairment, enlarged liver and spleen, large and square head, thick and short fingers. x-ray examination shows excessive ossification of the whole body, enlarged butterfly saddle, premature closure of the cranial suture, narrow proximal end of the rib cage and wide distal end, shaped like a floating belt. Mucopolysaccharide in the urine of the child is increased. 4, renal tubular acidosis: is congenital or acquired renal tubular dysfunction, causing growth retardation in children, accompanied by anorexia, fatigue, weakness, excessive drinking, polyuria, thirst, etc. X-ray examination can be seen in the long bones of osteoporosis and epiphyseal changes, calcification shadow in the kidney area, blood biochemistry shows hyperchloremic metabolic acidosis, low blood potassium, urine is mostly alkaline or neutral. 5. Cretinism: It is congenital hypothyroidism or absence, commonly known as cretinism (see endocrinopathy, hypothyroidism for details). 6, familial dwarf size: related to the family’s physical type, although there is a certain degree of deficiency in length, but its growth rate, bone and dental development, sexual maturity are normal, without any endocrine function abnormal performance. 8, growth disorders: one or two years after birth growth gradually slowed down, short, proportional, adult appearance still resembles children, subcutaneous fat, muscle is not developed; skeletal maturity delayed, bone age is smaller than age, intelligence and age equivalent. 9, sexual development disorders: male penis is small, cryptorchid, no beard, voice tone like a child. Females have no menstruation, undeveloped breasts, small uterus, infantile vulva, and no axillary hair.