Massive pancreatitis may become cancerous after cure. Massive pancreatitis is a kind of chronic pancreatitis, also known as pseudotumor pancreatitis. Since the course of mass pancreatitis extends for several years or even decades, the patient’s pancreas and the tissues around the pancreas are subjected to repeated inflammatory stimulation, and the cells can lead to cancerous transformation under repeated stimulation. Even if the disease has been cured, the repeated stimulation during the long course of the disease has been irreversible, so there is still a probability of cancerous transformation after cure. It is suggested that patients should pay attention to a light diet, avoid eating too greasy food, eat more vegetables and fruits, pay attention to the regularity of work and rest, and avoid staying up late to reduce the probability of recurrence of mass pancreatitis. Patients should pay attention to timely physical examination and review, and if cancer is found, treatment should be carried out as soon as possible to prevent the condition from deteriorating.