Carbon monoxide poisoning occurs mostly in winter and can cause damage to the central system or permanent damage. First aid mainly includes several aspects such as getting out of the poisoning environment, correcting hypoxia and preventing cerebral edema: 1. Get out of the poisoning environment: When carbon monoxide poisoning occurs, you should immediately open doors and windows, or quickly move the patient to fresh air, get out of the carbon monoxide poisoning environment, stop continuing to inhale carbon monoxide, and call the emergency number. Untie the collar and belt, pay attention to warmth, and keep the respiratory tract unobstructed. If there is respiratory arrest, cardiopulmonary resuscitation should be performed immediately; 2. Correct oxygen deficiency: carbon monoxide poisoning will form carboxyhemoglobin in the body, affecting the ability of hemoglobin to carry oxygen, which in turn affects the body’s oxygen supply, inhalation of oxygen can promote the dissociation of carboxyhemoglobin, but the effect is slow, it is recommended to use hyperbaric chamber for treatment. Hyperbaric oxygen chamber treatment can promote the rapid dissociation of carboxyhemoglobin, accelerate the clearance of carbon monoxide, reduce the death rate and shorten the course of the disease, and reduce or prevent the occurrence of late-onset encephalopathy. In addition, if respiratory arrest occurs, tracheal intubation should be performed and pure oxygen should be used for mechanical ventilation; 3. Prevention and control of cerebral edema: cerebral edema can occur in 2-4 hours in acute carbon monoxide poisoning and reach a peak in 24-48 hours, which can last for many days. Patients can be guided by professional doctors, intravenous rapid drip of mannitol or application of diuretics to relieve symptoms. In addition, adrenocorticotropic hormone can reduce the stress response of the body and help relieve cerebral edema; 4. Promote the recovery of brain cell function: B vitamins, cytochrome C, coenzyme A and cytidylcholine can be appropriately supplemented; 5. Prevent and treat complications: Patients need to strengthen nursing care during coma, keep the respiratory tract unobstructed and prevent the occurrence of lung infections and pressure sores.