Abnormal excitation of the nucleus accumbens and medial pallidum is the core of the pathophysiological changes in Parkinson’s disease, therefore, abnormal excitation of the nucleus accumbens can be eliminated by surgical means to relieve the symptoms. There are two main types of surgical treatments as follows: 1. Nucleus destruction: The abnormally excited nucleus in the brain is destroyed by radiofrequency thermocoagulation through stereotactic techniques to relieve symptoms. However, this surgery can only be done on one side, that is, to relieve the symptoms of one limb, while Parkinson’s disease usually has symptoms on both limbs, and this destruction is permanent and irreversible, if the destruction is too large, too small or inaccurate positioning of the destruction, it can bring about poor treatment results or complications, and more seriously, radiofrequency destruction has an inherent risk of cerebral hemorrhage, so the surgery has certain risks. 2.deepbrainstimulation (DBS): It is often called a brain pacemaker, and its shape is similar to that of a heart pacemaker. The surgery is performed by implanting a 1.27 mm diameter thick electrode into the nucleus accumbens in the brain and burying a pulse generator under the skin in the chest. The pulse generator sends electrical stimulation through the subcutaneous wire to the electrode in the brain, which acts on the abnormal excitatory nucleus in the brain to inhibit the abnormal neural discharge and eliminate the symptoms. DBS is a reversible neurostimulation treatment that can be implanted bilaterally in the brain, relieving the symptoms of both limbs in a single operation, which is currently the best surgical treatment in the world and the greatest progress in the treatment of Parkinson’s disease in the past 30-40 years. Patients with intermediate or advanced Parkinson’s disease who have obvious symptoms, unsatisfactory effect of medication, or large side effects of medication, and no serious cardiopulmonary disease are suitable for brain pacemaker treatment.