(Disclaimer: This article is for scientific purposes only, in order to protect the patient’s privacy, the relevant information in the following content has been processed) Abstract: This case is a young man of about 30 years old, because the left leg was smashed by the goods and squeezed three days ago, yesterday found that the left leg was swollen, distension and cracking sensation, the wound oozing blood, and accompanied by a bad smell, and at the same time, there was irritability, sweating, fever and other systemic symptoms, and then came to our hospital for treatment. He came to our hospital. Through X-ray examination and clinical manifestations, gas gangrene was finally diagnosed. Through antibiotic treatment, hyperbaric oxygen therapy and systemic supportive therapy, the patient’s symptoms were relieved. 【Basic information】 Male, 30 years old 【Disease type】 Gas gangrene 【Hospitalization】 The First Affiliated Hospital of Kunming Medical University 【Date of consultation】 December 2021 【Treatment plan】 Antibiotic treatment (injectable penicillin sodium) + Hyperbaric oxygen therapy + Systemic supportive therapy (blood transfusion, correction of water-electrolyte imbalance, nutritional support) 【Treatment cycle】 7 days of hospitalization, 1 month of outpatient follow-up 【Treatment effect】 The swelling and pain of the left leg was relieved. Swelling and pain in the left leg was relieved, blood seepage was reduced, sweating with fever disappeared, and malodor was reduced I. Initial Consultation Patient complained that his left leg was smashed by the goods and extruded 3 days ago, and was buried for 3 hours before he was rescued, and he only knew that the wound was deep and open, and he didn’t have any other symptom, so he just stopped the bleeding and bandaged it in the clinic, and didn’t go to the doctor. However, yesterday, the left leg appeared to be swollen, feeling distended, the wound oozing blood, with a foul odor, and at the same time the patient appeared irritable, sweating, fever and other manifestations. In addition, there was no history of gas gangrene in the patient’s family, and the patient had not taken any medication, so I suspected that the patient might be suffering from gas gangrene. In order to further clarify the diagnosis, I asked the patient to undergo X-ray examination, and the result suggested that multiple gas foci could be seen in the muscle planes of the left calf and thigh, and combined with the patient’s clinical manifestations, I thought that it was more likely to support gas gangrene. The X-ray examination suggested that multiple gas foci could be seen in the muscle plane of the left calf and thigh, and combined with the patient’s clinical symptoms, it could be diagnosed as gas gangrene. Antibiotic treatment was mainly carried out, and penicillin sodium for injection was preferred, and the dose needed to be large, which was due to the fact that Clostridium podoconiosis was mostly sensitive to penicillin. Hyperbaric oxygen therapy should also be used to increase the oxygen content between tissues and destroy the environment for bacterial growth and reproduction, and also combined with systemic supportive therapy, including blood transfusion, correction of water-electrolyte imbalance, nutritional support and symptomatic treatment. (X-rays showed multiple foci of gas visible in the muscle planes of the left calf and thigh. Combined with the medical history, it was consistent with the imaging changes of gas gangrene.) III. Treatment effect Gas gangrene progresses quickly, and its treatment principle is early diagnosis and immediate debridement of necrotic tissues as soon as diagnosis is made, combined with a large number of antibiotic treatments. After clearing and draining the wound, the patient’s left leg was swollen and painful; after getting relief from the application of penicillin, blood oozing was reduced, sweating was reduced and fever disappeared; after adopting hyperbaric oxygen therapy, the environment for the growth and reproduction of bacteria was destroyed, and the malodorous smell was reduced. At the same time, systemic supportive therapies for patients, such as blood transfusion, correction of water electrolyte imbalance, while ensuring nutrition, improved the immunity of patients. In summary, the patient’s clinical symptoms disappeared and he was successfully discharged from the hospital. IV. Precautions It is glad that the patient’s symptoms improved after treatment, but still need to pay attention to some matters in daily life: 1. Patients with gas gangrene need to have a light and balanced diet, more intake of easy-to-digest high protein, drink more water, and don’t eat stimulating food such as garlic, chili, seafood and so on. It is also necessary to keep good rest and pay attention to the regularity of life. Develop good living habits, quit smoking and drinking; 2, gas gangrene patients should pay attention to bed rest in a short period of time after debridement, and get out of bed as early as possible after the condition is recovered and the wound is healed, and they can have proper exercise every day to enhance their physique; 3, pay extra attention to the problem of infection after debridement, and deal with it in time when you find the skin whitish, swollen, and bubbles bubbles coming out of the trauma, and don’t delay the condition. Prevention and treatment of infection, once the abnormal situation should go to the hospital in time to avoid serious consequences. V. Personal perception Gas gangrene is an infectious disease caused by gas-producing anaerobic Clostridium difficile, forming soft tissue inflammation and necrosis deep to the muscle, mostly secondary to a variety of open wounds, with a few being spontaneous. In conclusion, patients with the same clinical manifestations as this case must not be taken lightly, because many gas gangrene can be prevented, and patients with open wounds should be admitted to the hospital as early as possible for formal management, which can effectively prevent the occurrence of this disease. Doctors should do a good job of disseminating scientific knowledge so that patients realize the seriousness of gas gangrene. Although the disease is relatively rare, it has an acute onset, rapid progression, and high rates of disability and mortality. But it should not cause anxiety, because early detection and treatment are the key.