(Disclaimer: This article is for scientific purposes only. In order to protect the patient’s privacy, the relevant information in the following content has been processed) Abstract: The patient was prescribed several pairs of Chinese medicines of unknown composition in a local clinic for a cold 1 week ago, and his whole body started to turn yellow after taking them, and his urine was very yellow, with a decrease in his appetite and generalized fatigue. The patient thought that there was a problem with his liver, so he came to our department. Outpatient review diagnosed as drug liver injury, after admission to the hospital through the administration of symptomatic drug therapy, the patient’s liver function gradually returned to normal, the skin color also returned to normal, eating also returned to normal and cured and discharged from the hospital. Basic information】Female, 55 years old 【Disease type】 Drug induced liver injury 【Hospital】 Liaocheng People’s Hospital 【Date of consultation】November 2021 【Treatment plan】Pharmacological treatment (Diammonium glycyrrhizinate enteric capsule for liver protection + Ursodeoxycholic Acid tablets) 【Treatment cycle】Inpatient treatment for 1 week, outpatient review after 2 weeks 【Treatment effect】Liver function gradually returned to normal, and the color of the skin returned to normal. Interview The patient reported liver problems, including yellowing of the body, yellowing of the urine, and lack of appetite, and came to check his liver because he was told it was a liver problem. Liver function tests and abdominal ultrasound were performed in the outpatient clinic. The liver function tests suggested elevated transaminases and bilirubin, and the abdominal ultrasound did not reveal any clear cases of bile duct stones or biliary tract tumors. At that time, it was suspected to be caused by hepatocellular injury, because the common causes of this disease are viral hepatitis, drugs or unknown reasons, and the patient had eaten some Chinese medicines with unknown ingredients 1 week ago, so it was suspected to be drug liver injury, and the patient was admitted to the hospital. Second, the treatment process After admission to the hospital, the patient was given a viral screening also to exclude common hepatitis B or C, and the patient was given an intensive CT and MRCP examination of the abdomen, which did not find any bile duct stones, liver tumors or biliary tract tumors, and the patient is now highly suspected of drug-related liver injury, which is related to the consumption of traditional Chinese medicines. Communicating with the patient’s family, we suggested that the patient should be treated according to the medication liver injury firstly, firstly, stop taking traditional Chinese medicine, and secondly, use some liver-protecting and choleretic medicines, and the patient’s family agreed with the above program, and then we gave diammonium glycyrrhizinate enteric capsule to protect the liver, and ursodeoxycholic acid tablets to be used for choleretic and symptomatic treatments. The patient’s skin color was obviously not so yellow on the 3rd day after drug treatment, the color of urine became lighter, the appetite was improved, and the amount of food gradually increased. Review of liver function, aminotransferases, bilirubin basically close to normal. According to the current treatment effect, it indicates that the treatment is effective, so the current diagnosis of the patient’s drug-induced liver injury is established. The patient was further improved the examination of autoimmune hepatitis related indexes, and no obvious abnormality was found, so the patient was cured and discharged after 1 week of treatment, and the patient was asked to come to the hospital for recheck in 2 weeks. Precautions We are glad that the patient’s symptoms have been improved after treatment, but still need to pay attention to some matters: 1, the diet at this stage should be based on light, well-digested food, and when the jaundice completely subsides and the digestive function returns to normal, then gradually transition to normal diet, which usually takes 1 week; 2, you should come to the hospital for review in about 2 weeks after discharge, and the items of the review are mainly liver function test and abdominal B ultrasound examination. The main items for review are liver function test and abdominal ultrasound. If the bilirubin and aminotransferase of the liver function test are still within the normal range, and no obvious abnormality is found in the abdominal ultrasound, it means that the effect of this treatment is more satisfactory, and the patient should be reminded to avoid taking drugs of unknown composition in the future. V. Personal perception In the clinical drug liver injury is also relatively common, the common reason is that the oral intake of some unknown components of the drug, or regular drugs but the adverse effects of liver injury. Because the patient in this case of hepatocellular injury, and its taking drugs of unknown composition has a great relationship, so the patient in the treatment of the disease should first of all consult a regular hospital, drug therapy should also choose a regular manufacturer, or have a clear drug composition of the drug. If the patient usually has drug liver injury, in the future treatment must avoid the use of some of the drugs that have adverse effects of liver injury, at the same time, if there is jaundice, loss of appetite and other adverse reactions, should be timely consultation.