We often say that “all drugs are poisonous”, drugs can cure diseases, but also have harmful to the human body, we often call the harmful reactions of drugs to the human body – adverse reactions. Rheumatoid arthritis patients and other rheumatism patients need to use drugs for a long time, many patients because of fear of adverse reactions and stop the drug, but also by many patients to increase or decrease the drug, these are undesirable, the former delayed the disease, the latter may bring more adverse reactions due to drug overdose. Drugs have adverse reactions, but not everyone has, that is poison, will not be used in clinical. There are individual differences in the occurrence of adverse drug reactions, and doctors do not know in which patients will appear, so it is more important to inform the doctor in a timely manner and review regularly when discomfort occurs. No adverse reactions to drugs, this is the advertising words of many drug dealers, but some drugs have more adverse reactions and some less, do not blindly believe. We hope that you can use these drugs properly while understanding the adverse effects of rheumatic drugs. What are the adverse effects of drugs for rheumatism? Digestive system: This is the most common adverse reaction among commonly used anti-rheumatic drugs. Anti-inflammatory and painkillers are the most common. Common adverse reactions include nausea, vomiting, diarrhea, dyspepsia, gastric and duodenal ulcers, and bleeding; in addition, drugs such as methotrexate and tretinoin can cause damage to the liver, thus causing an increase in liver transaminases. Urinary system: anti-inflammatory and painkilling drugs, which can dry up water and sodium metabolism, can occur edema, kidney damage, etc.; in addition, long-term use of immunosuppressive drugs can make the body resistance to decline, prone to urinary tract infections. Nervous system: Headache and vertigo are common. Some drugs can cause seizures. Hematological system: drugs with immunosuppressive effects can inhibit the hematopoietic function of bone marrow and cause anemia, leukopenia and thrombocytopenia. For example, methotrexate and cyclophosphamide. In addition, circulatory system symptoms, allergic reactions, teratogenic, carcinogenic and other adverse reactions can also occur. How to prevent the development of adverse reactions? Remember allergy history: This is especially important for patients with drug allergies. Maternal medication should be used with particular caution, especially in the first trimester of pregnancy, and any medication should be avoided. Reasonable dosing: Since rheumatic diseases are mostly treated with combined drugs, patients should not add drugs casually by themselves to avoid increasing adverse reactions. Observe the reaction after medication: During the process of medication, attention should be paid to detect the early symptoms of adverse drug reactions so as to facilitate timely discontinuation and treatment. Do not drink alcohol when taking medication: Alcohol contains ethanol, which can induce adverse drug reactions in addition to accelerating the metabolic transformation of certain drugs in the body and reducing their efficacy. Read the instructions carefully: regular follow-up – this is the most critical point, as long as we can do regular follow-up, basically can prevent adverse drug reactions