Traditional Chinese herbal medicine is considered “green and natural medicine”, and many people in China prefer Chinese herbal medicine for medical treatment, which has brought about frequent toxicity problems due to the abuse of Chinese herbal medicine. In recent years, there has been an increase in the number of adverse reactions caused by herbal medicines and their preparations, and cases of death from herbal poisoning have also been reported, and the safety of such treatment has been under attack. Many times patients taking herbal medicines and their preparations often do not explain them to their doctors, and therefore it is difficult to determine whether hepatotoxicity is present. The potential hepatotoxicity of herbal medicines is not new and has been described as early as in the book “The Compendium of Materia Medica”. Some plants, such as: bitter almond, cassava, broad bean root, northern bean root, mugwort, hairy wintergreen, yellow dock, cranberry, big maple, neem bark, fish bitter gall, millipede, and smallpox powder, are known to be hepatotoxic for a long time. The hepatotoxicity of herbal drugs can be the direct toxic effect of the drug itself or its metabolites, or the immune damage that occurs during the metabolism of the drug, and its clinical and pathological manifestations may be characteristic of various liver diseases. In addition, in addition to the toxic effect of the drug itself, the liver damage caused by Chinese medicine is also related to the following factors: 1, the residues of pesticides in cultivated herbs and species confusion, as well as indiscriminate and misuse, etc. Scholars from the National University of Singapore and National University Hospital reported that among the patients with acute liver failure they admitted from 1992 to 2008, 44.5% were caused by hepatitis B virus infection and 36.6% were caused by drug-induced liver injury Among them, those caused by Chinese medicine accounted for 42% of drug-related liver injury. 2, there are misconceptions about Chinese medicine. Such as “natural drugs are not toxic” propaganda misleading, in fact, the herbal medicine, medical books and modern textbooks have a clear discussion, such as breaking the stasis of the Chinese medicine should not be taken for a long time, a long time to take easy to hurt the right qi. Chinese medicine is not equal to health care products. If Chinese medicine is taken as “vitamin” for a long time, toxic side effects are inevitable. 3. Chinese medicine or proprietary Chinese medicine is not applied in accordance with the basic theory of Chinese medicine. Such as the application of Chai Hu preparations, etc. After 1997, the number of new cases of liver damage reported by proprietary Chinese medicines decreased significantly. 4, related to the quality control of drug preparations and primary drugs. Such as strong bone joint pill adverse reactions were mainly seen before 1995, since then there has been a significant reduction. 5, indiscriminate use, misuse or overdose. For example, among 427 cases of liver damage caused by taking herbal medicines in one hospital, 2 cases were misused, 15 cases were taken for a long time, and 62 cases took over-the-counter drugs. In conclusion, herbal medicines are not as safe as they are usually claimed to be. Therefore, herbs should be carefully evaluated for true therapeutic efficacy and toxicity, and the possible hepatotoxicity caused by herbs should be well understood to avoid misdiagnosis. Caution must also be exercised when administering herbs and they should not be abused.