The patient’s thumb is painful, but not red or swollen. Initially, it may be caused by tenosynovitis. It is mostly seen in people who are engaged in hand labor for a long time, or who use cell phones and computers for a long time. The overuse of the thumb leads to chronic strain on the muscles and joints of the thumb, which in turn causes a sterile inflammation of the tendon sheath, often accompanied by pain and ringing fingers. In addition, the following diseases are not excluded: 1. tendon sheath cyst: often occurs on the palmar and dorsal side of the wrist joint, usually patients have obvious swelling at the wrist, and when the joint is active, the thumb has symptoms such as restricted abduction and pain, but there is no redness, swelling and other manifestations; 2. rheumatoid arthritis: most of this disease is slow and insidious onset, patients may have fever, fatigue, weakness, night sweats and other early Systemic symptoms. Often developed by small joints, such as the thumb, arthralgia and pressure pain is the earliest symptom. If there is a pre-performance, and the pain of the thumb is symmetrical, it is recommended to go to the rheumatology department of the hospital in time; 3, palmar tendon contracture: If the thumb area does not have redness and swelling, but the pain is severe, and is accompanied by symptoms such as flexion contracture of the thumb, inability to straighten, functional limitations, etc., consider that it may be caused by palmar tendon contracture. However, it usually occurs in the ring finger and the little finger, and is relatively rare in the thumb. The cause of the disease is unclear, and may be closely related to the patient’s race, age, genetics, etc.; 4, peripheral neuritis: mainly due to poisoning, nutritional metabolic disorders, infection and other factors, the patient’s fingers, wrists, legs and other extremity parts will appear the performance of skin cold, as well as pins and needles, ants, burning and other nature of pain and discomfort, generally no redness and swelling; 5, cervical spondylosis: the patient exists cervical 5, cervical spondylosis: patients with cervical disc and its accessory structure lesions, will cause stimulation or compression of the spinal cord, nerves, blood vessels, etc., which will lead to pain, numbness, weakness and other discomfort in the entire upper limbs.