Papilloma is generally a benign tumor originating from epithelial cells in some parts of the body, which can appear in different parts of the body and usually has a low malignancy rate. The early symptoms may vary due to different sites, and the common ones mainly include anal papilloma, cervical papilloma, esophageal papilloma, etc.: 1. Anal papilloma: a pale hard nodule growing on the anal dentition line, which usually grows in the anus with the constant stimulation of inflammation or feces and can be prolapsed outside the anus. In the early stage, it may manifest as a feeling of unclean bowel movement or a feeling of anal swelling caused by sinusitis, which is usually detected during anal finger examination. 2. It is usually detected and removed by vaginal endoscopy during gynecological examination; 3. Esophageal papilloma: It is an abnormal proliferation of squamous epithelium of esophageal mucosa, which is generally benign and has no symptoms in early stage, but can be detected by gastroscopy if it is located in the upper part of the esophagus with foreign body sensation in swallowing; 4. 5. Intraductal papilloma: benign tumors occurring in the nipple or areola area, which can occur in both men and women. The earliest symptom is usually the appearance of fluid in the nipple, and as the disease develops, breast lumps can be palpated.