OBJECTIVE: To investigate the design method of the implant bar-retained prosthetic restoration for maxillary defects with edentulism. METHODS: In one case of maxillary defect with edentulism, a maxillary hollow prosthesis was fabricated using the bar-retained implant retention method. RESULTS: After clinical follow-up from 3 to 12 months, the implant bar-clamped prosthetic restoration of maxillary defect with edentulism had a good retention effect, effectively restored oral function, and was aesthetically pleasing, comfortable, and easy to remove and wear. CONCLUSION: The dentist should make precise implant placement according to the remaining bone quality and the restoration concept, and choose the most suitable implant retention method to fabricate the maxillary defect with edentulism prosthesis in order to achieve satisfactory results. The key to the restoration of maxillary defects with edentulism is to obtain good retention of the prosthesis. In order to solve this problem, scholars have successively proposed the use of segmental maxillary prostheses, segmental prostheses with silicone rubber blockers and magnetic attachments, implant prostheses with magnetic attachments, and implant prostheses with pestle and mortar attachments for the restoration of unilateral maxillary defects in edentulous patients. In particular, the use of implant and bone grafting techniques has significantly improved the retention of maxillary pseudoprostheses. The authors used the combination of implant and bar-clamp retainer for solving the retention problem of unilateral maxillary defect restoration in edentulous patients, and achieved good retention effect, effectively restored the oral function, and also had the advantages of easy to take and wear, easy to self-cleaning, and aesthetic.